Evidence map›Paper›PMID 29760388›Full record

ArticleNature communications2018

Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma.

Jeffrey P North, Justin Golovato, Charles J Vaske, J Zachary Sanborn, Andrew Nguyen, Wei Wu, Benjamin Goode, Meredith Stevers, Kevin McMullen, Bethany E Perez White and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
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  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Advancing Cancer Research: Current Knowledge on Cutaneous Neoplasia.International journal of molecular sciences · 2023
    Review
  16. Sebaceous Neoplasms.Diagnostics (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jeffrey P NorthDepartment of Dermatology, University of California, San Francisco, CA, 94115, USA.ORCID http://orcid.org/0000-0003-3973-5314
Justin GolovatoNantOmics, LLC, Culver City, CA, 90232, USA.
Charles J VaskeNantOmics, LLC, Culver City, CA, 90232, USA.ORCID http://orcid.org/0000-0001-8151-6612
J Zachary SanbornNantOmics, LLC, Culver City, CA, 90232, USA.
Andrew NguyenNantOmics, LLC, Culver City, CA, 90232, USA.
Wei WuSkin Tissue Engineering Core and Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
Benjamin GoodeDepartment of Pathology, University of California, San Francisco, CA, 94143, USA.
Meredith SteversDepartment of Pathology, University of California, San Francisco, CA, 94143, USA.
Kevin McMullenDepartment of Dermatology, University of California, San Francisco, CA, 94115, USA.
Bethany E Perez WhiteSkin Tissue Engineering Core and Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.ORCID http://orcid.org/0000-0002-5594-0599
Eric A CollissonDepartment of Hematology and Oncology, University of California, San Francisco, CA, 94158, USA.
Michele BloomerDepartment of Pathology, University of California, San Francisco, CA, 94143, USA.
David A SolomonDepartment of Pathology, University of California, San Francisco, CA, 94143, USA.ORCID http://orcid.org/0000-0003-4571-7999
Stephen C BenzNantOmics, LLC, Culver City, CA, 90232, USA.
Raymond J ChoDepartment of Dermatology, University of California, San Francisco, CA, 94115, USA. Raymond.cho@ucsf.edu.ORCID http://orcid.org/0000-0001-6090-6603

Funding

The Role of Keratinocytes as Independent ThermosensorsP30AR057216 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PALLER, AMY S · 2009 to 2018
$6.0M
Cohesin gene mutations in tumorigenesisDP5OD021403 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOLOMON, DAVID A. · 2015 to 2019
$2.0M
NIAMS NIH HHS P30 AR057216NIH HHS DP5 OD021403
6 · The paper itself

Abstract

Sebaceous carcinomas (SeC) are cutaneous malignancies that, in rare cases, metastasize and prove fatal. Here we report whole-exome sequencing on 32 SeC, revealing distinct mutational classes that explain both cancer ontogeny and clinical course. A UV-damage signature predominates in 10/32 samples, while nine show microsatellite instability (MSI) profiles. UV-damage SeC exhibited poorly differentiated, infiltrative histopathology compared to MSI signature SeC (p = 0.003), features previously associated with dissemination. Moreover, UV-damage SeC transcriptomes and anatomic distribution closely resemble those of cutaneous squamous cell carcinomas (SCC), implicating sun-exposed keratinocytes as a cell of origin. Like SCC, this UV-damage subclass harbors a high somatic mutation burden with >50 mutations per Mb, predicting immunotherapeutic response. In contrast, ocular SeC acquires far fewer mutations without a dominant signature, but show frequent truncations in the ZNF750 epidermal differentiation regulator. Our data exemplify how different mutational processes convergently drive histopathologically related but clinically distinct cancers.

Indexed as

Microsatellite InstabilityMutationCarcinoma, Squamous CellDiagnosis, DifferentialDNA Mutational AnalysisExomeExome SequencingEye NeoplasmsHumansKeratinocytesMicrosatellite RepeatsSebaceous Gland NeoplasmsSkin NeoplasmsTerminology as TopicTranscriptomeUltraviolet Rays

Identifiers

PMID29760388
PMCPMC5951856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.