Evidence map›Paper›PMID 29760282›Full record

ArticleMolecular and cellular biology2018

The Caenorhabditis elegans Ortholog of TDP-43 Regulates the Chromatin Localization of the Heterochromatin Protein 1 Homolog HPL-2.

Tassa K Saldi, Patrick Gonzales, Alfonso Garrido-Lecca, Vishantie Dostal, Christine M Roberts, Leonard Petrucelli, Christopher D Link

Open access · hybridAbstract read
In one paragraph

Article in Molecular and cellular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Invertebrate genetic models of amyotrophic lateral sclerosis.Frontiers in molecular neuroscience · 2024
    Review
  3. TDP-43 Epigenetic Facets and Their Neurodegenerative Implications.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Frontiers in aging · 2022
    Review
  8. Article
  9. Article
  10. Review
  11. TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons.Biochimica et biophysica acta. Gene regulatory mechanisms · 2019
    Article
  12. Article
  13. Neurodegeneration, Heterochromatin, and Double-Stranded RNA.Journal of experimental neuroscience · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tassa K SaldiDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA.ORCID 0000-0002-5648-1355
Patrick GonzalesIntegrative Physiology, University of Colorado, Boulder, Colorado, USA.
Alfonso Garrido-LeccaDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA.
Vishantie DostalIntegrative Physiology, University of Colorado, Boulder, Colorado, USA.
Christine M RobertsIntegrative Physiology, University of Colorado, Boulder, Colorado, USA.
Leonard PetrucelliDepartment of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Christopher D LinkIntegrative Physiology, University of Colorado, Boulder, Colorado, USA linkc@colorado.edu.
University of Colorado Boulder · USJacksonville College · US

Funding

TDP-43, RNA Metabolism, and ALS/FTD PathologyR01NS063964 · NINDS · UNIVERSITY OF COLORADO · PI LINK, CHRISTOPHER D. · 2009 to 2019
$3.5M
NINDS NIH HHS R01 NS063964
6 · The paper itself

Abstract

TDP-1 is the

Indexed as

Alternative SplicingAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCell NucleusChromatinChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDNA-Binding ProteinsGene DeletionGenes, HelminthHumansNeurodegenerative DiseasesRNA-Binding ProteinsRNA, HelminthCaenorhabditis elegans ProteinsChromatinChromobox Protein Homolog 5Chromosomal Proteins, Non-HistoneDNA-Binding ProteinsHPL-2 protein, C elegansNRDE-3 protein, C elegansRNA-Binding ProteinsRNA, HelminthTARDBP protein, humanTDP-1 protein, C elegansChIP-seqchromatindsRNAneurodegenerationRNA-seq

Identifiers

PMID29760282
PMCPMC6048318
OpenAlexW2804494174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.