Evidence map›Paper›PMID 29760211›Full record

ReviewJournal of bacteriology2018

Updates to Clostridium difficile Spore Germination.

Travis J Kochan, Matthew H Foley, Michelle S Shoshiev, Madeline J Somers, Paul E Carlson, Philip C Hanna

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Journal of bacteriology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07221370 (Enteral Vancomycin as Primary Prophylaxis Against Clostridioides Difficile Infection in Critically Ill Patients), which is not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07221370 phase2 / phase3recruitingnot on this mapstarted 2024, after this paper: background citation

Enteral Vancomycin as Primary Prophylaxis Against Clostridioides Difficile Infection in Critically Ill Patients

TypeinterventionalSponsorRiverside University Health System Medical CenterRan2024 to 2026Enrolled176ConditionsClostridium Difficile Infection, Vancomycin Resistant Enterococci InfectionArmsVancomycin 125mg, Placebo
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Cytotoxic synergism ofWorld journal of gastroenterology · 2023
    Review
  8. Review
  9. Make It LessGenes · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. The impact of dietary fibers onFrontiers in cellular and infection microbiology · 2022
    Article
  16. Opportunities for Nanomedicine inAntibiotics (Basel, Switzerland) · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Journal of inflammation research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Travis J KochanUniversity of Michigan, Department of Microbiology and Immunology, Ann Arbor, Michigan, USA.
Matthew H FoleyUniversity of Michigan, Department of Microbiology and Immunology, Ann Arbor, Michigan, USA.
Michelle S ShoshievUniversity of Michigan, Department of Microbiology and Immunology, Ann Arbor, Michigan, USA.
Madeline J SomersUniversity of Michigan, Department of Microbiology and Immunology, Ann Arbor, Michigan, USA.
Paul E CarlsonU.S. Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, Maryland, USA.
Philip C HannaUniversity of Michigan, Department of Microbiology and Immunology, Ann Arbor, Michigan, USA pchanna@umich.edu.
University of Michigan–Ann Arbor · USUnited States Food and Drug Administration · US

Funding

Characterization of the Mechanism of Glycine induced Germination of Clostridium difficile SporesF31AI126651 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOCHAN, TRAVIS JOSEPH · 2016 to 2018
$81k
NIAID NIH HHS F31 AI126651
6 · The paper itself

Abstract

Germination of

Indexed as

Bacillus anthracisBacterial ProteinsClostridioides difficileClostridium InfectionsClostridium perfringensHumansMembrane ProteinsSpores, BacterialBacterial ProteinsMembrane ProteinsClostridium difficilegerminationspores

Identifiers

PMID29760211
PMCPMC6060349
OpenAlexW2804831184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.