Evidence map›Paper›PMID 29760176›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Postnatal Ablation of Synaptic Retinoic Acid Signaling Impairs Cortical Information Processing and Sensory Discrimination in Mice.

Esther Park, Michelle Tjia, Yi Zuo, Lu Chen

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Esther ParkDepartments of Neurosurgery, Neuropsychiatry and Behavioral Sciences, Stanford Neuroscience Institute, Stanford University School of Medicine, Stanford, California 94305-5453, and.ORCID 0000-0002-1594-7753
Michelle TjiaDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064.ORCID 0000-0003-1210-8775
Yi ZuoDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, California 95064 luchen1@stanford.edu yizuo@ucsc.edu.ORCID 0000-0001-9020-0003
Lu ChenDepartments of Neurosurgery, Neuropsychiatry and Behavioral Sciences, Stanford Neuroscience Institute, Stanford University School of Medicine, Stanford, California 94305-5453, and luchen1@stanford.edu yizuo@ucsc.edu.ORCID 0000-0002-8097-2699
University of California, Santa Cruz · USStanford Medicine · USStanford University · US

Funding

Developmental Pathophysiology of Synapses in a Mouse Model of Fragile X SyndromeR01HD084215 · NICHD · STANFORD UNIVERSITY · PI CHEN, LU · 2014 to 2018
$3.3M
Regulation of synaptic transmission by retinoic acid signalingR01MH091193 · NIMH · STANFORD UNIVERSITY · PI CHEN, LU · 2011 to 2015
$2.3M
Dynamics and molecular mechanism of synaptic connectivity change during learningR01MH104227 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2014 to 2018
$2.1M
Contribution of astrocytes to the Fragile X SyndromeR01MH109475 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2016 to 2020
$2.0M
Neurovascular Mechanisms of Time-Dependencies in Stroke RehabilitationR01NS078791 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K, JONES, THERESA A · 2012 to 2016
$1.7M
NICHD NIH HHS R01 HD084215NIMH NIH HHS R01 MH091193NIMH NIH HHS R01 MH104227NIMH NIH HHS R01 MH109475NINDS NIH HHS R01 NS078791
6 · The paper itself

Abstract

Retinoic acid (RA) and its receptors (RARs) are well established essential transcriptional regulators during embryonic development. Recent findings in cultured neurons identified an independent and critical post-transcriptional role of RA and RARα in the homeostatic regulation of excitatory and inhibitory synaptic transmission in mature neurons. However, the functional relevance of synaptic RA signaling

Indexed as

AnimalsFemaleMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutPerceptionRetinoic Acid Receptor alphaSignal TransductionSomatosensory CortexSynaptic TransmissionTretinoinRetinoic Acid Receptor alphaTretinoinenriched environmentretinoic acid signalingsensory deprivationsensory discriminationsomatosensory cortex

Identifiers

PMID29760176
PMCPMC5990979
OpenAlexW2803526563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.