Evidence map›Paper›PMID 29760125›Full record

ArticleAntimicrobial agents and chemotherapy2018

Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti-Flaviviridae Activity.

Quentin Nevers, Isaac Ruiz, Nazim Ahnou, Flora Donati, Rozenn Brillet, Laurent Softic, Maxime Chazal, Nolwenn Jouvenet, Slim Fourati, Camille Baudesson and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Non-Immunosuppressive Cyclophilin Inhibitors.Angewandte Chemie (International ed. in English) · 2022
    Review
  6. Review
  7. Cyclophilin A: a key player for etiological agent infection.Applied microbiology and biotechnology · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Quentin Nevers *Institut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Isaac Ruiz *Institut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Nazim AhnouInstitut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Flora DonatiInstitut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Rozenn BrilletInstitut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Laurent SofticInstitut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Maxime ChazalUnité Génomique Virale et Vaccination, CNRS UMR 3569, Institut Pasteur, Paris, France.
Nolwenn JouvenetUnité Génomique Virale et Vaccination, CNRS UMR 3569, Institut Pasteur, Paris, France.
Slim FouratiInstitut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Camille BaudessonInstitut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Patrice BruscellaInstitut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Muriel GelinCentre de Biochimie Structurale, INSERM, CNRS, Université de Montpellier, Montpellier, France.
Jean-François GuichouCentre de Biochimie Structurale, INSERM, CNRS, Université de Montpellier, Montpellier, France.
Jean-Michel Pawlotsky *Institut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France.
Abdelhakim Ahmed-Belkacem *Institut Mondor de Recherche Biomédicale, INSERM U955 Team 18, Hôpital Henri Mondor, Université Paris-Est, Créteil, France hakim.ahmed-belkacem@inserm.fr.
Inserm · FRCentre de Biologie Structurale · FRCentre National de la Recherche Scientifique · FRDepartment of Virology · FRInstitut Mondor de Recherche Biomédicale · FRInstitut Pasteur · FRUniversité Paris-Est Créteil · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although members of the

Indexed as

Amino Acid SubstitutionAntiviral AgentsCyclophilin ACyclosporineDrug Resistance, ViralHepacivirusHepatitis CHumansRNA-Dependent RNA PolymeraseViral Nonstructural ProteinsVirus ReplicationalisporivirAntiviral AgentsCyclophilin ACyclosporineNS-5 protein, hepatitis C virusRNA-Dependent RNA PolymeraseViral Nonstructural Proteinsantiviral agentsbroad-spectrum antiviral activitycyclophilin inhibitorsFlaviviridaehepatitis C virusresistancesmall molecule

Identifiers

PMID29760125
PMCPMC6021681
OpenAlexW2802458639

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.