ArticleProceedings of the National Academy of Sciences of the United States of America2018
Functional organization of intrinsic and feedback presynaptic inputs in the primary visual cortex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Depicting Primate-Like Granular Dorsolateral Prefrontal Cortex in the Chinese Tree Shrew.eNeuro · 2024Article
- Beyond a Transmission Cable-New Technologies to Reveal the Richness in Axonal Electrophysiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Heterosynaptic plasticity-induced modulation of synapses.The journal of physiological sciences : JPS · 2023Review
- Cellular and laminar architecture: A short history and commentary.The Journal of comparative neurology · 2023Article
- Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation.Neuroscience bulletin · 2023Article
- Resting-State Neuronal Activity and Functional Connectivity Changes in the Visual Cortex after High Altitude Exposure: A Longitudinal Study.Brain sciences · 2022Article
- Eavesdropping wires: Recording activity in axons using genetically encoded calcium indicators.Journal of neuroscience methods · 2021Review
- Article
- Role of Feedback Connections in Central Visual Processing.Annual review of vision science · 2020Review
- Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons.Nature communications · 2020Article
Corrections and comments
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In the primary visual cortex (V1) of many mammalian species, neurons are spatially organized according to their preferred orientation into a highly ordered map. However, whether and how the various presynaptic inputs to V1 neurons are organized relative to the neuronal orientation map remain unclear. To address this issue, we constructed genetically encoded calcium indicators targeting axon boutons in two colors and used them to map the organization of axon boutons of V1 intrinsic and V2-V1 feedback projections in tree shrews. Both connections are spatially organized into maps according to the preferred orientations of axon boutons. Dual-color calcium imaging showed that V1 intrinsic inputs are precisely aligned to the orientation map of V1 cell bodies, while the V2-V1 feedback projections are aligned to the V1 map with less accuracy. Nonselective integration of intrinsic presynaptic inputs around the dendritic tree is sufficient to reproduce cell body orientation preference. These results indicate that a precisely aligned map of intrinsic inputs could reinforce the neuronal map in V1, a principle that may be prevalent for brain areas with function maps.
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