ArticleProceedings of the National Academy of Sciences of the United States of America2018
Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 73 citations in OpenAlex.
- Broadband amplification of organ of Corti vibrations in the mouse cochlear apex.bioRxiv : the preprint server for biology · 2026Article
- Composite Certainty: Addressing Metric Degeneracy in Parameter Inference for Model-Based Diagnostics.bioRxiv : the preprint server for biology · 2026Article
- Composite Biofidelity: Addressing Metric Degeneracy in Biomechanical Model Validation and Machine Learning Loss Design.bioRxiv : the preprint server for biology · 2026Article
- An alternative pathway for delivery of power by outer hair cells to cochlear traveling waves.Hearing research · 2026Article
- Cochlear endoplasmic reticulum stress causes connexin 26 degradation is involved in age-related hearing loss.iScience · 2025Article
- Longitudinal Vibrations in the Organ of Corti are Limited to Its Core.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Simulation-based inference for subject-specific tuning of middle ear finite-element models towards personalized objective diagnosis.Scientific reports · 2025Article
- Evaluation of thin-slice finite-element models for 3D cochlear organ of Corti mechanics.Hearing research · 2025Article
- How the Human Cochlea Moves: Biomechanical Modeling of a Wide, Layered Osseous Spiral Lamina.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Narrow elliptical motion at the outer hair cell-Deiters' cell junction explains disparate features of uniaxial displacement measurements.Hearing research · 2025Article
- 3D Computational Modeling of Blast Transmission through the Fluid-Filled Cochlea and Hair Cells.Annals of biomedical engineering · 2025Article
- The Reduced Cortilymph Flow Path in the Short-Wave Region Allows Outer Hair Cells to Produce Focused Traveling-Wave Amplification.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Corti Fluid Is a Medium for Outer Hair Cell Force Transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- From Simulations to Inference: Using Machine Learning to Tune Patient-Specific Finite-Element Models of the Middle Ear Towards Objective Diagnosis.bioRxiv : the preprint server for biology · 2024Article
- Asymmetric vibrations in the organ of Corti by outer hair cells measured from excised gerbil cochlea.Communications biology · 2024Article
- Intracochlear overdrive: Characterizing nonlinear wave amplification in the mouse apex.The Journal of the Acoustical Society of America · 2023Article
- Otoacoustic emissions reveal the micromechanical role of organ-of-Corti cytoarchitecture in cochlear amplification.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Broad nonlinearity in reticular lamina vibrations requires compliant organ of Corti structures.Biophysical journal · 2023Article
- Crucial 3-D viscous hydrodynamic contributions to the theoretical modeling of the cochlear response.The Journal of the Acoustical Society of America · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The field of cochlear mechanics has been undergoing a revolution due to recent findings made possible by advancements in measurement techniques. While it has long been assumed that basilar-membrane (BM) motion is the most important determinant of sound transduction by the inner hair cells (IHCs), it turns out that other parts of the sensory epithelium closer to the IHCs, such as the reticular lamina (RL), move with significantly greater amplitude for weaker sounds. It has not been established how these findings are related to the complex cytoarchitecture of the organ of Corti between the BM and RL, which is composed of a lattice of asymmetric Y-shaped elements, each consisting of a basally slanted outer hair cell (OHC), an apically slanted phalangeal process (PhP), and a supporting Deiters' cell (DC). Here, a computational model of the mouse cochlea supports the hypothesis that the OHC micromotors require this Y-shaped geometry for their contribution to the exquisite sensitivity and frequency selectivity of the mammalian cochlea. By varying only the OHC gain parameter, the model can reproduce measurements of BM and RL gain and tuning for a variety of input sound levels. Malformations such as reversing the orientations of the OHCs and PhPs or removing the PhPs altogether greatly reduce the effectiveness of the OHC motors. These results imply that the DCs and PhPs must be properly accounted for in emerging OHC regeneration therapies.
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