Evidence map›Paper›PMID 29760073›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Regulation of myeloid cell phagocytosis by LRRK2 via WAVE2 complex stabilization is altered in Parkinson's disease.

Kwang Soo Kim, Paul C Marcogliese, Jungwoo Yang, Steve M Callaghan, Virginia Resende, Elizabeth Abdel-Messih, Connie Marras, Naomi P Visanji, Jana Huang, Michael G Schlossmacher and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
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  8. Article
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  11. TheScience translational medicine · 2024
    Article
  12. Review
  13. Article
  14. bioRxiv : the preprint server for biology · 2024
    Article
  15. Causal role of myeloid cells in Parkinson's disease: Mendelian randomization study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  16. Review
  17. Review
  18. Article
  19. ASO-mediated knockdown or kinase inhibition ofMolecular therapy. Nucleic acids · 2023
    Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Kwang Soo KimDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Paul C MarcoglieseDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0002-8011-7852
Jungwoo YangDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Steve M CallaghanDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.ORCID 0000-0001-6692-4060
Virginia ResendeDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Elizabeth Abdel-MessihDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Connie MarrasMorton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, ON M5T 2S8, Canada.
Naomi P VisanjiMorton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, ON M5T 2S8, Canada.
Jana HuangEdmond J. Safra Program in Parkinson's Disease, University of Toronto, Toronto, ON M5S 1A8, Canada.
Michael G SchlossmacherBrain and Mind Research Institute, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Laura Trinkle-MulcahyDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Ruth S SlackDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Anthony E LangMorton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, ON M5T 2S8, Canada.
Canadian Lrrk2 in Inflammation Team (CLINT)
David S ParkDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada; dpark@uottawa.ca.ORCID 0000-0002-4490-3784
University of Ottawa · CAUniversity Health Network · CAUniversity of Toronto · CA

Funding

CIHR 148402
6 · The paper itself

Abstract

Leucine-rich repeat kinase 2 (

Indexed as

AnimalsCell LineCytophagocytosisDrosophilaHumansLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MiceMicrogliaMyeloid CellsParkinson DiseaseSignal TransductionWiskott-Aldrich Syndrome Protein FamilyLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanWASF2 protein, humanWiskott-Aldrich Syndrome Protein FamilyLRRK2microgliaParkinson’s diseaseWASF2WAVE2

Identifiers

PMID29760073
PMCPMC5984500
OpenAlexW2803478714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.