ArticleProceedings of the National Academy of Sciences of the United States of America2018
Spatial mutation patterns as markers of early colorectal tumor cell mobility.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Spatially Discontinuous Mutation Topographies in Ductal Carcinoma In Situ Reveal Noncompetitive Growth Dynamics.Cancer research · 2025Article
- Evolutionary paths towards metastasis.Nature reviews. Cancer · 2025Review
- A quantitative characterization of the heterogeneous response of glioblastoma U-87 MG cell line to temozolomide.Scientific reports · 2025Article
- Evolutionary measures show that recurrence of DCIS is distinct from progression to breast cancer.Breast cancer research : BCR · 2025Article
- Spatial interactions modulate tumor growth and immune infiltration.NPJ systems biology and applications · 2024Article
- Mechanisms of metastatic colorectal cancer.Nature reviews. Gastroenterology & hepatology · 2024Review
- Evolutionary Measures Show that Recurrence of DCIS is Distinct from Progression to Breast Cancer.medRxiv : the preprint server for health sciences · 2024Article
- Spatial interactions modulate tumor growth and immune infiltration.Research square · 2024Article
- Spatial interactions modulate tumor growth and immune infiltration.bioRxiv : the preprint server for biology · 2024Article
- Tumour Growth Mechanisms Determine Effectiveness of Adaptive Therapy in Glandular Tumours.Interdisciplinary sciences, computational life sciences · 2024Article
- Article
- Review
- Mutation divergence over space in tumour expansion.Journal of the Royal Society, Interface · 2023Article
- Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast Development.bioRxiv : the preprint server for biology · 2023Article
- Impact of crowding on the diversity of expanding populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- First passage time analysis of spatial mutation patterns reveals sub-clonal evolutionary dynamics in colorectal cancer.PLoS computational biology · 2023Article
- Where Are We Now and Where Might We Be Headed in Understanding and Managing Brain Metastases in Colorectal Cancer Patients?Current treatment options in oncology · 2022Review
- Dynamic phenotypic heterogeneity and the evolution of multiple RNA subtypes in hepatocellular carcinoma: the PLANET study.National science review · 2022Article
- Spatial structure governs the mode of tumour evolution.Nature ecology & evolution · 2022Article
- Development and Clinical Validation of a Blood Test for Early Detection of Colorectal Adenomas and Cancer for Screening and Postpolypectomy Surveillance.Gastro hep advances · 2022Article
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4 authors.
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Abstract
A growing body of evidence suggests that a subset of human cancers grows as single clonal expansions. In such a nearly neutral evolution scenario, it is possible to infer the early ancestral tree of a full-grown tumor. We hypothesized that early tree reconstruction can provide insights into the mobility phenotypes of tumor cells during their first few cell divisions. We explored this hypothesis by means of a computational multiscale model of tumor expansion incorporating the glandular structure of colorectal tumors. After calibrating the model to multiregional and single gland data from 19 human colorectal tumors using approximate Bayesian computation, we examined the role of early tumor cell mobility in shaping the private mutation patterns of the final tumor. The simulations showed that early cell mixing in the first tumor gland can result in side-variegated patterns where the same private mutations could be detected on opposite tumor sides. In contrast, absence of early mixing led to nonvariegated, sectional mutation patterns. These results suggest that the patterns of detectable private mutations in colorectal tumors may be a marker of early cell movement and hence the invasive and metastatic potential of the tumor at the start of the growth. In alignment with our hypothesis, we found evidence of early abnormal cell movement in 9 of 15 invasive colorectal carcinomas ("born to be bad"), but in none of 4 benign adenomas. If validated with a larger dataset, the private mutation patterns may be used for outcome prediction among screen-detected lesions with unknown invasive potential.
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