Evidence map›Paper›PMID 29759949›Full record

ReviewTrends in immunology2018

The Glycoscience of Immunity.

Julie Y Zhou, Douglas M Oswald, Kelsey D Oliva, Lori S C Kreisman, Brian A Cobb

Open access · greenAbstract readReview
In one paragraph

Review in Trends in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 83 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. M2-Like Macrophages Exhibit Sialic Acid-Enhanced Efferocytosis via the Siglec CD22.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  5. The Role of Glycans in Human Immunity-A Sweet Code.Molecules (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Article
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  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
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  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Julie Y ZhouCase Western Reserve University School of Medicine, Department of Pathology, USA.
Douglas M OswaldCase Western Reserve University School of Medicine, Department of Pathology, USA.
Kelsey D OlivaCase Western Reserve University School of Medicine, Department of Pathology, USA.
Lori S C KreismanCase Western Reserve University School of Medicine, Department of Pathology, USA.
Brian A CobbCase Western Reserve University School of Medicine, Department of Pathology, USA. Electronic address: brian.cobb@case.edu.
Case Western Reserve University · US

Funding

Regulatory Mechanisms of Glycoprotein SialylationR01GM115234 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI Brian A Cobb · 2016 to 2026
$5.1M
Immunology Training Program-PredoctoralT32AI089474 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2010 to 2025
$3.4M
Antigenic Carbohydrate Structure, Function, and SpecificityR01GM082916 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI COBB, BRIAN A · 2009 to 2016
$1.9M
NIAID NIH HHS T32 AI089474NIGMS NIH HHS R01 GM082916NIGMS NIH HHS R01 GM115234
6 · The paper itself

Abstract

Carbohydrates, or glycans, are as integral to biology as nucleic acids and proteins. In immunology, glycans are well known to drive diverse functions ranging from glycosaminoglycan-mediated chemokine presentation and selectin-dependent leukocyte trafficking to the discrimination of self and non-self through the recognition of sialic acids by Siglec (sialic acid-binding Ig-like lectin) receptors. In recent years, a number of key immunological discoveries are driving a renewed and burgeoning appreciation for the importance of glycans. In this review, we highlight these findings which collectively help to define and refine our knowledge of the function and impact of glycans within the immune response.

Indexed as

AnimalsChemokinesHumansImmunityLeukocytesPolysaccharidesSialic Acid Binding Immunoglobulin-like LectinsChemokinesPolysaccharidesSialic Acid Binding Immunoglobulin-like Lectins

Identifiers

PMID29759949
PMCPMC6029714
OpenAlexW2799394015

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.