Evidence map›Paper›PMID 29759930›Full record

ArticleParkinsonism & related disorders2018

Diagnostic criteria for camptocormia in Parkinson's disease: A consensus-based proposal.

Alfonso Fasano, Christian Geroin, Alfredo Berardelli, Bastiaan R Bloem, Alberto J Espay, Mark Hallett, Anthony E Lang, Michele Tinazzi

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07010328 (Efficacy of Integrating Artificial Intelligence Solutions in Rehabilitation in Postural Trunk Disorders in Parkinson's Disease.), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07010328 narecruitingnot on this mapstarted 2024, after this paper: background citation

Efficacy of Integrating Artificial Intelligence Solutions in Rehabilitation in Postural Trunk Disorders in Parkinson's Disease.

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2024 to 2028Enrolled20ConditionsParkinson Disease, Physical Inactivity, Physical Disability, Pisa SyndromeArmsNeurorehabilitation, AI-based home rehabilitation for postural disorders
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
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  17. Management of Pain in Parkinson's Disease.Journal of Parkinson's disease · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Alfonso FasanoEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Research Institute, Toronto, Ontario, Canada. Electronic address: alfonso.fasano@uhn.ca.
Christian GeroinNeuromotor and Cognitive Rehabilitation Research Center (CRRNC), Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. Electronic address: christian.geroin@univr.it.
Alfredo BerardelliDepartment of Human Neurosciences, Sapienza, University of Rome and IRCCS Neuromed Institute Pozzilli (IS), Italy. Electronic address: alfredo.berardelli@uniroma1.it.
Bastiaan R BloemRadboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Nijmegen, The Netherlands. Electronic address: Bas.Bloem@radboudumc.nl.
Alberto J EspayGardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA. Electronic address: aespay@gmail.com.
Mark HallettHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA. Electronic address: hallettm@ninds.nih.gov.
Anthony E LangEdmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada; Krembil Research Institute, Toronto, Ontario, Canada. Electronic address: lang@uhnresearch.ca.
Michele TinazziNeurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. Electronic address: michele.tinazzi@univr.it.
University of Toronto · CAUniversity of Verona · ITIstituto Neurologico Mediterraneo · ITNational Institute of Neurological Disorders and Stroke · USRadboud University Nijmegen · NLUniversity of Cincinnati · US

Funding

Pathophysiology of Basal Ganglia DisordersZIANS003031 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI HALLETT, MARK · 2009 to 2023
$22.7M
Intramural NIH HHS ZIA NS003031
6 · The paper itself

Abstract

introductionCamptocormia is defined as an involuntary, marked flexion of the thoracolumbar spine appearing during standing or walking and resolving in the supine position or when leaning against a wall. However, there is no established agreement on the minimum degree of forward flexion needed to diagnose camptocormia. Likewise, the current definition does not categorize camptocormia on the basis of the bending fulcrum.

methodsWe performed a survey among movement disorders experts to identify camptocormia using images of patients with variable degrees and types of forward trunk flexion by fulcrum (upper and lower fulcra). We tested the subsequently generated diagnostic criteria in a sample of 131 consecutive patients referred for evaluation of postural abnormalities.

resultsExperts reached full consensus on lower camptocormia (L1-Sacrum, hip flexion) with a bending angle ≥30° and upper camptocormia (C7 to T12-L1) with a bending angle ≥45°. This definition detected camptocormia in 9/131 consecutive PD patients (2 upper/7 lower) but excluded camptocormia in 71 patients considered to have camptocormia by the referring neurologist.

conclusionsCamptocormia can be defined as "an involuntary flexion of the spine appearing during standing or walking and resolving in the supine position of at least 30° at the lumbar fulcrum (L1-Sacrum, hip flexion, i.e. lower camptocormia) and/or at least 45° at the thoracic fulcrum (C7 to T12-L1, i.e. upper camptocormia)". Strict criteria for camptocormia are met by 7% of patients with abnormal posture. The ascertainment of upper and lower camptocormia subtypes could improve the validity of epidemiological studies and assist future therapeutic trials.

Indexed as

Muscular Atrophy, SpinalParkinson DiseaseSpinal CurvaturesAgedAged, 80 and overConsensus Statements as TopicFemaleHumansMaleMiddle AgedPrevalenceBack painBent spine syndromeCamptocormiaPostural abnormalitiesStooped posture

Identifiers

PMID29759930
PMCPMC7293065
OpenAlexW2799674410

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.