ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2018
Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Multivariate brain-behaviour associations in psychiatric disorders.Translational psychiatry · 2024Pooled it
- Morphometric Analysis of Structural MRI Using Schizophrenia Meta-analytic Priors Distinguish Patients from Controls in Two Independent Samples and in a Sample of Individuals With High Polygenic Risk.Schizophrenia bulletin · 2022Pooled it
- A technical review of canonical correlation analysis for neuroscience applications.Human brain mapping · 2020Pooled it
- Dynamic multivariate patterns of brain structure-neuropsychiatric symptom associations in long COVID.Brain communications · 2026Article
- The BAsic NeuroCognitive Continuum (BANCC): Delineation of dimensional and categorical features for etiological and treatment investigations of idiopathic psychosis.Psychiatry and clinical neurosciences · 2025Article
- Multivariate patterns among multimodal neuroimaging and clinical, cognitive, and daily functioning characteristics in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- White Matter, Cognition, and Electrophysiological Variables in Bipolar Disorder: Using Multimodal Integration of Biomarker Variables Associated With Bipolar Disorder to Elucidate Deficits.Bipolar disorders · 2025Article
- Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Supervised machine learning classification of psychosis biotypes based on brain structure: findings from the Bipolar-Schizophrenia network for intermediate phenotypes (B-SNIP).Scientific reports · 2023Article
- Emotional scene processing in biotypes of psychosis.Psychiatry research · 2023Article
- Understanding the relationship between cerebellar structure and social abilities.Molecular autism · 2023Article
- Multivariate analytical approaches for investigating brain-behavior relationships.Frontiers in neuroscience · 2023Article
- Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Social Cognitive Networks and Social Cognitive Performance Across Individuals With Schizophrenia Spectrum Disorders and Healthy Control Participants.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Neural Processing of Repeated Emotional Scenes in Schizophrenia, Schizoaffective Disorder, and Bipolar Disorder.Schizophrenia bulletin · 2021Article
- Article
- Cortical Morphometric Abnormality and Its Association with Working Memory in Children with Attention-Deficit/Hyperactivity Disorder.Psychiatry investigation · 2021Article
- BIOMARKERS AND NEUROBEHAVIORAL DIAGNOSIS.Biomarkers in neuropsychiatry · 2021Article
- Stability test of canonical correlation analysis for studying brain-behavior relationships: The effects of subject-to-variable ratios and correlation strengths.Human brain mapping · 2021Article
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Abstract
backgroundCognitive and structural brain abnormalities range from mild to severe in psychosis. The relationships of specific cognitive functions to specific brain structures across the psychosis spectrum is less certain.
methodsParticipants (n = 678) with bipolar, schizoaffective, or schizophrenia psychoses and healthy control subjects were recruited via the Bipolar-Schizophrenia Network for Intermediate Phenotypes. The Schizo-Bipolar Scale was used to create a psychosis continuum (from purely affective to purely nonaffective). Canonical correlation between 14 cognitive measures and structural brain measures (gray matter volume, cortical thickness, cortical surface area, and local gyrification indices) for 68 neocortical regions yielded constructs that defined shared cognition-brain structure relationships. Canonical discriminant analysis was used to integrate these constructs and efficiently summarize cognition-brain structure relationships across the psychosis continuum.
resultsGeneral cognition was associated with larger gray matter volumes and thicker cortices but smaller cortical surface area in frontoparietal regions. Working memory was associated with larger volume and surface area in frontotemporal regions. Faster response speed was associated with thicker frontal cortices. Constructs that captured general cognitive ability and working memory and their relationship to cortical volumes primarily defined an ordered psychosis spectrum (purely affective, least abnormal through purely nonaffective, and most abnormal). A construct that captured general cognitive ability and its relationship to cortical surface area differentiated purely affective cases from other groups.
conclusionsGeneral cognition and working memory with cortical volume deviations characterized more nonaffective psychoses. Alternatively, affective psychosis cases with general cognitive deficits had deviations in cortical surface area, perhaps accounting for heterogeneous findings across previous studies.
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