ArticleBiomaterials2018
Recyclable magnetic nanoparticles grafted with antimicrobial metallopolymer-antibiotic bioconjugates.
Article in Biomaterials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Resonance-Based Sensing of Magnetic Nanoparticles Using Microfluidic Devices with Ferromagnetic Antidot Nanostructures.Nanomaterials (Basel, Switzerland) · 2023Article
- Membrane-Active Metallopolymers: Repurposing and Rehabilitating Antibiotics to Gram-Negative Superbugs.Advanced healthcare materials · 2023Article
- Facial amphiphilic naphthoic acid-derived antimicrobial polymers against multi-drug resistant gram-negative bacteria and biofilms.Biomaterials · 2023Article
- Facially Amphiphilic Bile Acid-Functionalized Antimicrobials: Combating Pathogenic Bacteria, Fungi, and Their Biofilms.ACS infectious diseases · 2023Article
- In-vivo processing of nanoassemblies: a neglected framework for recycling to bypass nanotoxicological therapeutics.Toxicology research · 2023Review
- Biodegradable polycaprolactone metallopolymer-antibiotic bioconjugates containing phenylboronic acid and cobaltocenium for antimicrobial application.Biomaterials science · 2021Article
- Synthesis and antibacterial activity of polymer-antibiotic conjugates incorporated into a resin-based dental adhesive.Biomaterials science · 2021Article
- Facile In-Situ Fabrication of a Ternary ZnO/TiOAntibiotics (Basel, Switzerland) · 2021Article
- Metallo-Polyelectrolytes: Correlating Macromolecular Architectures with Properties and Applications.Trends in chemistry · 2020Article
- Electrochemical Preparation of Synergistic Nanoantimicrobials.Molecules (Basel, Switzerland) · 2019Article
- Antibacterial magnetic nanoparticles for therapeutics: a review.IET nanobiotechnology · 2019Review
- Crystallization-Driven Self-Assembly of Metallo-Polyelectrolyte Block Copolymers with a Polycaprolactone Core-Forming Segment.ACS macro letters · 2019Article
- A perspective on magnetic core-shell carriers for responsive and targeted drug delivery systems.International journal of nanomedicine · 2019Review
- Macromolecular-clustered facial amphiphilic antimicrobials.Nature communications · 2018Article
- Metallo-polyelectrolytes as a class of ionic macromolecules for functional materials.Nature communications · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Over-prescription and improper use of antibiotics has led to the emergence of bacterial resistance, posing a major threat to public health. There has been significant interest in the development of alternative therapies and agents to combat antibiotic resistance. We report the preparation of recyclable magnetic iron oxide nanoparticles grafted with charged cobaltocenium-containing metallopolymers by surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization. β-Lactam antibiotics were then conjugated with metallopolymers to enhance their vitality against both Gram-positive and Gram-negative bacteria. The enhanced antibacterial activity was a result of synergy of antimicrobial segments that facilitate the inhibition of hydrolysis of antibiotics and local enhancement of antibiotic concentration on a nanoparticle surface. These magnetic nanoparticles can be recycled numerous times without losing the initial antimicrobial potency. Studies suggested negligible toxicity of metallopolymer-grafted nanoparticles to red blood cells and minimal tendency to induce resistance in bacteria.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.