Evidence map›Paper›PMID 29759550›Full record

ReviewCritical reviews in oncology/hematology2018

Sarcoma-The standard-bearer in cancer discovery.

Jared W Potter, Kevin B Jones, Jared J Barrott

Open access · hybridAbstract readReview
In one paragraph

Review in Critical reviews in oncology/hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
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  11. Article
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  13. Review
  14. Review
  15. Article
  16. CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets.International journal of molecular sciences · 2020
    Review
  17. Article
  18. Immunotherapeutic strategies for sarcoma: current perspectives.American journal of translational research · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jared W PotterDepartment of Orthopaedics, University of Utah Huntsman Cancer Institute, Salt Lake City, UT 84112, United States.
Kevin B JonesDepartment of Orthopaedics, University of Utah Huntsman Cancer Institute, Salt Lake City, UT 84112, United States.
Jared J BarrottDepartment of Biomedical and Pharmaceutical Sciences, Idaho State University, Pocatello, ID 83209, United States. Electronic address: barrjare@isu.edu.
University of Utah · USIdaho State University · US

Funding

Epigenetic Mechanisms Driving Synovial SarcomagenesisR01CA201396 · NCI · UNIVERSITY OF UTAH · PI CAIRNS, BRADLEY R., JONES, KEVIN BRUCE · 2017 to 2021
$1.7M
NCI NIH HHS R01 CA201396
6 · The paper itself

Abstract

Sarcoma is a rare tumor type that occurs most frequently in connective tissue. Despite its uncommon occurrence, sarcoma research has provided the means for groundbreaking research that has advanced our understanding of general cancer mechanisms. It is through sarcoma research that the pioneering efforts of cancer immunotherapy were explored, that we understand the inherent genetic nature of cancer mutations, and that we appreciate the subclassification of general cancer types to make more accurate prognoses. This review explores the brief history of sarcoma research and what sarcomas can still teach us about the future of cancer research, especially in regard to novel immunotherapy targets, the role of epigenetics in disease progression and chemoresistance, and the benefits of more focused clinical trials.

Indexed as

SarcomaBiomedical ResearchDrug DiscoveryDrug Resistance, NeoplasmEpigenesis, GeneticHumansImmunotherapyMutationPrognosisChemoresistanceEpigeneticsImmunotherapyMutational burdenSarcoma

Identifiers

PMID29759550
PMCPMC5961738
OpenAlexW2794795407

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.