Evidence map›Paper›PMID 29759069›Full record

ArticleBMC medicine2018

Guillain-Barré syndrome risk among individuals infected with Zika virus: a multi-country assessment.

Luis Mier-Y-Teran-Romero, Mark J Delorey, James J Sejvar, Michael A Johansson

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in BMC medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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  9. Bystander activated CD8Nature communications · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Luis Mier-Y-Teran-RomeroDivision of Vector-Borne Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico. lmier-y@jhsph.edu.
Mark J DeloreyDivision of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
James J SejvarDivision of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Michael A JohanssonDivision of Vector-Borne Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico.
Centers for Disease Control and Prevention · USHarvard University · USPuerto Rico Department of Health · PR

Funding

Understanding and controlling antibiotic resistanceU54GM088558 · NIGMS · HARVARD SCHOOL OF PUBLIC HEALTH · PI HANAGE, WILLIAM · 2009 to 2018
$26.4M
Models of Infectious Disease Agent Study Program 1U54GM088558NIGMS NIH HHS U54 GM088558
6 · The paper itself

Abstract

backgroundCountries with ongoing outbreaks of Zika virus have observed a notable rise in reported cases of Guillain-Barré syndrome (GBS), with mounting evidence of a causal link between Zika virus infection and the neurological syndrome. However, the risk of GBS following a Zika virus infection is not well characterized. In this work, we used data from 11 locations with publicly available data to estimate the risk of GBS following an infection with Zika virus, as well as the location-specific incidence of infection and the number of suspect GBS cases reported per infection.

methodsWe built a mathematical inference framework utilizing data from 11 locations that had reported suspect Zika and GBS cases, two with completed outbreaks prior to 2015 (French Polynesia and Yap) and nine others in the Americas covering partial outbreaks and where transmission was ongoing as of early 2017.

resultsWe estimated that 2.0 (95% credible interval 0.5-4.5) reported GBS cases may occur per 10,000 Zika virus infections. The frequency of reported suspect Zika cases varied substantially and was highly uncertain, with a mean of 0.11 (95% credible interval 0.01-0.24) suspect cases reported per infection.

conclusionsThese estimates can help efforts to prepare for the GBS cases that may occur during Zika epidemics and highlight the need to better understand the relationship between infection and the reported incidence of clinical disease.

Indexed as

Disease OutbreaksFemaleGuillain-Barre SyndromeHumansIncidenceMaleZika VirusZika Virus InfectionGuillain–Barré syndromeneurological disordervector-borne diseasesZika virus

Identifiers

PMID29759069
PMCPMC5952697
OpenAlexW2805473026

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.