ArticleTechnology in cancer research & treatment2018
Electrochemotherapy of Spinal Metastases Using Transpedicular Approach-A Numerical Feasibility Study.
Article in Technology in cancer research & treatment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Locoregional Treatment of Bone Metastases in a Lung Cancer Patient: A Case Report Using Multiple Techniques: Electrochemotherapy, Cryoablation, and Cementoplasty.Reports (MDPI) · 2026Article
- The Rising Power of Electrochemotherapy in Musculoskeletal Oncology.Current oncology (Toronto, Ont.) · 2026Review
- Maximal feasible resection versus hybrid therapy in spinal metastases: an updated narrative review.World journal of surgical oncology · 2025Review
- Electrochemotherapy of spinal metastasis using transpedicular approach: a preclinical safety animal study.European radiology experimental · 2025Article
- Application of a new coaxial bipolar electrode for the treatment of vertebral metastases: a pilot study in an ovine model.Frontiers in medicine · 2025Article
- Electrochemotherapy in Spine Metastases: A Case Series Focused on Technical Aspects, Surgical Strategies and Results.Diagnostics (Basel, Switzerland) · 2024Article
- Electrochemotherapy in Aggressive Hemangioma of the Spine: A Case Series and Narrative Literature Review.Journal of clinical medicine · 2024Article
- Optimization of Transpedicular Electrode Insertion for Electroporation-Based Treatments of Vertebral Tumors.Cancers · 2022Article
- Electrochemotherapy Is Effective in the Treatment of Bone Metastases.Current oncology (Toronto, Ont.) · 2022Article
- Electrochemotherapy treatment safety under parallel needle deflection.Scientific reports · 2022Article
- Percutaneous image guided electrochemotherapy of hepatocellular carcinoma: technological advancement.Radiology and oncology · 2020Article
- Recent Advances in Electrochemotherapy.Bioelectricity · 2019Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebral column is the most frequent site for bone metastases. It has been demonstrated in previous studies that bone metastases can be efficiently treated by electrochemotherapy. We developed a novel approach to treat spinal metastases, that is, transpedicular approach that combines electrochemotherapy with already established technologies for insertion of fixation screws in spinal surgery. In the transpedicular approach, needle electrodes are inserted into the vertebral body through pedicles and placed around the tumor. The main goal of our study was to numerically investigate the feasibility of the proposed treatment approach. Three clinical cases were used in this study-1 with a tumor completely contained within the vertebral body and 2 with tumors spread also to the pedicles and spinal canal. Anatomically accurate numerical models were built for all 3 cases, and numerical computations of electric field distribution in tumor and surrounding tissue were performed to determine the treatment outcome. Complete coverage of tumor volume with sufficiently high electric field is a prerequisite for successful electrochemotherapy. Close to 100% tumor coverage was obtained in all 3 cases studied. Two cases exhibited tumor coverage of >99%, while the coverage in the third case was 98.88%. Tumor tissue that remained untreated was positioned on the margin of the tumor volume. We also evaluated hypothetical damage to spinal cord and nerves. Only 1 case, which featured a tumor grown into the spinal canal, exhibited potential risk of neural damage. Our study shows that the proposed transpedicular approach to treat spinal metastases is feasible and safe if the majority of tumor volume is contained within the vertebral body. In cases where the spinal cord and nerves are contained within the margin of the tumor volume, a successful and safe treatment is still possible, but special attention needs to be given to evaluation of potential neural damage.
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