ArticleCortex; a journal devoted to the study of the nervous system and behavior2018
Alterations in the microstructure of white matter in children and adolescents with Tourette syndrome measured using tract-based spatial statistics and probabilistic tractography.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Premonitory urge in tic disorders - a scoping review.Frontiers in psychiatry · 2025Pooled it
- Microstructural Abnormalities of White Matter Across Tourette Syndrome: A Voxel-Based Meta-Analysis of Fractional Anisotropy.Frontiers in neurology · 2021Pooled it
- White matter microstructural abnormalities in children with Tourette syndrome using tract-based spatial statistics analysis.Japanese journal of radiology · 2026Article
- Diffusion indices alteration in major white matter tracts of children with tic disorder using TRACULA.Journal of neurodevelopmental disorders · 2024Article
- Elevated representational similarity of voluntary action and inhibition in Tourette syndrome.Brain communications · 2023Article
- Allopregnanolone: The missing link to explain the effects of stress on tic exacerbation?Journal of neuroendocrinology · 2022Review
- White matter alterations in drug-naïve children with Tourette syndrome and obsessive-compulsive disorder.Frontiers in neurology · 2022Article
- Altered frontal-mediated inhibition and white matter connectivity in pediatric chronic tic disorders.Experimental brain research · 2021Article
- A Rare NovelFrontiers in psychiatry · 2020Article
- Deep brain stimulation for Tourette's syndrome.Translational neurodegeneration · 2020Review
- Tourette syndrome research highlights from 2018.F1000Research · 2019Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Tourette syndrome (TS) is a neurodevelopmental disorder characterised by repetitive and intermittent motor and vocal tics. TS is thought to reflect fronto-striatal dysfunction and the aetiology of the disorder has been linked to widespread alterations in the functional and structural integrity of the brain. The aim of this study was to assess white matter (WM) abnormalities in a large sample of young patients with TS in comparison to a sample of matched typically developing control individuals (CS) using diffusion MRI. The study included 35 patients with TS (3 females; mean age: 14.0 ± 3.3) and 35 CS (3 females; mean age: 13.9 ± 3.3). Diffusion MRI data was analysed using tract-based spatial statistics (TBSS) and probabilistic tractography. Patients with TS demonstrated both marked and widespread decreases in axial diffusivity (AD) together with altered WM connectivity. Moreover, we showed that tic severity and the frequency of premonitory urges (PU) were associated with increased connectivity between primary motor cortex (M1) and the caudate nuclei, and increased information transfer between M1 and the insula, respectively. This is to our knowledge the first study to employ both TBSS and probabilistic tractography in a sample of young patients with TS. Our results contribute to the limited existing literature demonstrating altered connectivity in TS and confirm previous results suggesting in particular, that altered insular function contributes to increased frequency of PU.
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