Observational studyPhysiology & behavior2018
Differences in swallow physiology in patients with left and right hemispheric strokes.
Observational study in Physiology & behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Integrated analysis of the prevalence and influencing factors of poststroke dysphagia.European journal of medical research · 2025Pooled it
- Prevalence of dysphagia and risk of pneumonia and mortality in acute stroke patients: a meta-analysis.BMC geriatrics · 2022Pooled it
- The Effectiveness of Repetitive Transcranial Magnetic Stimulation for Post-stroke Dysphagia: A Systematic Review and Meta-Analysis.Frontiers in human neuroscience · 2022Pooled it
- The Role of White Matter in the Neural Control of Swallowing: A Systematic Review.Frontiers in human neuroscience · 2021Pooled it
- Effect of a Video-Guided Swallowing Exercise Program on Adherence in Stroke Patients with Dysphagia: A Randomized Controlled Trial.Dysphagia · 2026Trial
- Efficacy and Neurophysiological Mechanisms of 10 Hz Repetitive Transcranial Magnetic Stimulation for Post-Stroke Dysphagia: A Randomized Controlled Trial.Revista de neurologia · 2026Trial
- Cortical Activation and Functional Connectivity Changes during Swallowing in Patients with Dysphagia in Lateral Medullary Syndrome.Dysphagia · 2026Article
- Article
- White Matter Microstructural Correlates of Swallowing Biomechanics: An Exploratory Pilot Study in Healthy Young Adults.Dysphagia · 2025Article
- Review
- Anatomical predictors of gastrostomy tube placement after large vessel occlusion ischemic stroke.Frontiers in neurology · 2025Article
- Health Factors Associated With Development and Severity of Poststroke Dysphagia: An Epidemiological Investigation.Journal of the American Heart Association · 2024Article
- Review
- Cerebral small vessel disease is an independent determinant of dysphagia after acute stroke.NeuroImage. Clinical · 2024Observational
- Structural and functional asymmetry of the neonatal cerebral cortex.Nature human behaviour · 2023Article
- Research hotspots and trends in post-stroke dysphagia: a bibliometric analysis.Frontiers in neuroscience · 2023Article
- Structural Validity, Internal Consistency, and Rater Reliability of the Modified Barium Swallow Impairment Profile: Breaking Ground on a 52,726-Patient, Clinical Data Set.Journal of speech, language, and hearing research : JSLHR · 2022Article
- Swallowing function after acute ischemic stroke: Development and validation of a novel clinical prognostic model.Frontiers in nutrition · 2022Article
- Modulating swallowing-related functional connectivity and behaviorFrontiers in neurology · 2022Article
- Cortical and Subcortical Control of Swallowing-Can We Use Information From Lesion Locations to Improve Diagnosis and Treatment for Patients With Stroke?American journal of speech-language pathology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWe sought to determine the impact of lesion lateralization and lesion volume on swallow impairment on group-level by comparing patients with left and right hemisphere strokes and on patient-level by analyzing patients individually.
methodsWe performed a retrospective, observational, cross-sectional study of 46 patients with unilateral (22 left, 24 right), acute, first-ever, ischemic strokes who received a diffusion weighted MRI (DW-MRI) and modified barium swallow study (MBSS) during their acute hospital stay. We determined lesion side on the DW-MRI and measured swallow physiology using the Modified Barium Swallow Impairment Profile (MBSImP™©), Penetration-Aspiration Scale (PAS), swallow timing, distance, area, and speed measures. We performed Pearson's Chi-Square and Wilcoxon Rank-Sum tests to compare patients with left and right hemisphere strokes, and Pearson or Spearman correlation, simple logistic regression, linear, and logistic multivariable regression modeling to assess the relationship between variables.
resultsAt the group-level, there were no differences in MBSImP oral swallow impairment scores between patients with left and right hemisphere stroke. In adjusted analyses, patients with right hemisphere strokes showed significantly worse MBSImP pharyngeal total scores (p = 0.02), worse MBSImP component specific scores for laryngeal vestibular closure (Bonferroni adjusted alpha p ≤ 0.0029), and worse PAS scores (p = 0.03). Patients with right hemisphere strokes showed worse timing, distance, area, and speed measures. Lesion volume was significantly associated with MBSImP pharyngeal residue (p = 0.03) and pharyngeal total scores (p = 0.04). At the patient-level, 24% of patients (4 left, 7 right) showed opposite patterns of MBSImP oral and pharyngeal swallow impairment than seen at group-level.
conclusionOur study showed differences in swallow physiology between patients with right and left unilateral strokes with patients with right hemisphere strokes showing worse pharyngeal impairment. Lesion lateralization seems to be a valuable marker for the severity of swallowing impairment at the group-level but less informative at the patient-level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.