ArticleMedical physics2018
The reduction in treatment efficiency at high acoustic powers during MR-guided transcranial focused ultrasound thalamotomy for Essential Tremor.
Article in Medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- From Skull Density Ratio-based eligibility to efficiency-informed planning: Predictive modeling of thermal response in MR-guided focused ultrasound.Medical physics · 2026Article
- A figure of merit for transcranial ultrasound transmission based on coupled elastic-thermal analysis.Physics in medicine and biology · 2025Article
- A retraced spiral strategy with semi-automatic deblurring for volumetric thermometry.Magnetic resonance in medicine · 2025Article
- Direct targeting for focused ultrasound thalamotomy in the treatment of movement disorders: a retrospective cohort study.medRxiv : the preprint server for health sciences · 2025Article
- FAT1-weighted MRI-guided focused ultrasound thalamotomy for essential tremor.BMJ neurology open · 2025Article
- The influence of bone model geometries on the determination of skull acoustic properties.International journal for numerical methods in biomedical engineering · 2023Article
- Longitudinal MR imaging after unilateral MR-guided focused ultrasound thalamotomy: clinical and radiological correlation.Frontiers in neurology · 2023Article
- Spatio-Spectral Ultrasound Characterization of Reflection and Transmission Through Bone With Temperature Dependence.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Current state of therapeutic focused ultrasound applications in neuro-oncology.Journal of neuro-oncology · 2022Review
- Clinical Intervention Using Focused Ultrasound (FUS) Stimulation of the Brain in Diverse Neurological Disorders.Frontiers in neurology · 2022Review
- Factors Associated with Heating Efficiency in Transcranial Focused Ultrasound Therapy.Neurologia medico-chirurgica · 2020Article
- Predicting Bone Marrow Damage in the Skull After Clinical Transcranial MRI-Guided Focused Ultrasound With Acoustic and Thermal Simulations.IEEE transactions on medical imaging · 2020Article
- Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results from two phase I trials.Molecular psychiatry · 2020Article
- A Noninvasive Ultrasound Resonance Method for Detecting Skull Induced Phase Shifts May Provide a Signal for Adaptive Focusing.IEEE transactions on bio-medical engineering · 2020Article
- Simultaneous multislice MRI thermometry with a single coil using incoherent blipped-controlled aliasing.Magnetic resonance in medicine · 2020Article
- Essential tremor: New advances.Clinical parkinsonism & related disorders · 2020Review
- Elementwise approach for simulating transcranial MRI-guided focused ultrasound thermal ablation.Physical review research · 2019Article
- A rapid beam simulation framework for transcranial focused ultrasound.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo analyze clinical data indicating a reduction in the induced energy-temperature efficiency relationship during transcranial focused ultrasound (FUS) Essential Tremor (ET) thalamotomy treatments at higher acoustic powers, establish its relationship with the spatial distribution of the focal temperature elevation, and explore its cause.
methodsA retrospective observational study of patients (n = 19) treated between July 2015 and August 2016 for (ET) by FUS thalamotomy was performed. These data were analyzed to compare the relationships between the applied power, the applied energy, the resultant peak temperature achieved in the brain, and the dispersion of the focal volume. Full ethics approval was received and all patients provided signed informed consent forms before the initiation of the study. Computer simulations, animal experiments, and clinical system tests were performed to determine the effects of skull heating, changes in brain properties and transducer acoustic output, respectively. All animal procedures were approved by the Animal Care and Use Committee and conformed to the guidelines set out by the Canadian Council on Animal Care. MATLAB was used to perform statistical analysis.
resultsThe reduction in the energy efficiency relationship during treatment correlates with the increase in size of the focal volume at higher sonication powers. A linear relationship exists showing that a decrease in treatment efficiency correlates positively with an increase in the focal size over the course of treatment (P < 0.01), supporting the hypothesis of transient skull and tissue heating causing acoustic aberrations leading to a decrease in efficiency. Changes in thermal conductivity, perfusion, absorption rates in the brain, as well as ultrasound transducer acoustic output levels were found to have minimal effects on the observed reduction in efficiency.
conclusionsThe reduction in energy-temperature efficiency during high-power FUS treatments correlated with observed increases in the size of the focal volume and is likely caused by transient changes in the tissue and skull during heating.
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