Trial reportPloS one2018
Decreased circulating T regulatory lymphocytes in obese patients undergoing bariatric surgery.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- tVNS and obesity-related inflammation: a prospective sham-controlled randomized crossover study protocol.BMC psychology · 2026Article
- Review
- Sex Differences in the Impact of Obesity on Immunity.Immunological reviews · 2026Review
- Metabolic syndrome and its effect on immune cells in apical periodontitis- a narrative review.Clinical oral investigations · 2025Review
- T cells in obesity-associated inflammation: The devil is in the details.Immunological reviews · 2024Review
- Regulatory T cells and bioenergetics of peripheral blood mononuclear cells linked to pediatric obesity.Immunometabolism (Cobham, Surrey) · 2024Article
- Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells.Biomolecules · 2024Article
- Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T Cells in Human Hypertension.JACC. Basic to translational science · 2023Article
- Laparoscopic sleeve gastrectomy for morbid obesity improves gut microbiota balance, increases colonic mucosal-associated invariant T cells and decreases circulating regulatory T cells.Surgical endoscopy · 2022Article
- Interferon gamma mediates the reduction of adipose tissue regulatory T cells in human obesity.Nature communications · 2022Article
- The role of obesity and bariatric surgery-induced weight loss in breast cancer.Cancer metastasis reviews · 2022Review
- Revisiting the role of IL-1 signaling in the development of apical periodontitis.Frontiers in dental medicine · 2022Article
- Translating MSC Therapy in the Age of Obesity.Frontiers in immunology · 2022Review
- The Immunophenotyping Changes of Peripheral CD4+ T Lymphocytes and Inflammatory Markers of Class III Obesity Subjects After Laparoscopic Gastric Sleeve Surgery - A Follow-Up Study.Journal of inflammation research · 2021Article
- Obesity and immune status in children.Current opinion in pediatrics · 2020Review
- Obesity-associated T-cell and macrophage activation improve partly after a lifestyle intervention.International journal of obesity (2005) · 2020Article
- Interplay between the Adaptive Immune System and Insulin Resistance in Weight Loss Induced by Bariatric Surgery.Oxidative medicine and cellular longevity · 2019Review
- Novel Immunomodulatory Cytokine Regulates Inflammation, Diabetes, and Obesity to Protect From Diabetic Nephropathy.Frontiers in pharmacology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIt has been previously demonstrated that T lymphocytes may be involved in the development of hypertension and microvascular remodeling, and that circulating T effector lymphocytes may be increased in hypertension. In particular, Th1 and Th 17 lymphocytes may contribute to the progression of hypertension and microvascular damage while T-regulatory (Treg) lymphocytes seem to be protective in this regard. However, no data is available about patients with severe obesity, in which pronounced microvascular alterations were observed. DESIGN AND
methodsWe have investigated 32 severely obese patients undergoing bariatric surgery, as well as 24 normotensive lean subjects and 12 hypertensive lean subjects undergoing an elective surgical intervention. A peripheral blood sample was obtained before surgery for assessment of CD4+ T lymphocyte subpopulations. Lymphocyte phenotype was evaluated by flow cytometry in order to assess T-effector and Treg lymphocytes.
resultsA marked reduction of several Treg subpopulations was observed in obese patients compared with controls, together with an increased in CD4+ effector memory T-effector cells.
conclusionIn severely obese patients, Treg lymphocytes are clearly reduced and CD4+ effector memory cells are increased. It may be hypothesized that they might contribute to the development of marked microvascular alterations previously observed in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.