ArticlePloS one2018
Phylogenetic relationships, biofilm formation, motility, antibiotic resistance and extended virulence genotypes among Escherichia coli strains from women with community-onset primitive acute pyelonephritis.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 33 citations in OpenAlex.
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- Biofilm formation and antimicrobial resistance pattern of uropathogenic E. coli ST131 isolated from children with malignant tumors.The Journal of antibiotics · 2024Article
- Analysis ofFrontiers in cellular and infection microbiology · 2024Article
- Differential expression of urease genes and ureolytic activity of uropathogenic Escherichia coli and Pseudomonas aeruginosa isolates in different nutritional conditions.Archives of microbiology · 2023Article
- Quinolone resistance and biofilm formation capability of uropathogenic Escherichia coli isolates from an Iranian inpatients' population.Molecular biology reports · 2023Article
- Incidence of biofilms among the multidrug resistant E. coli, isolated from urinary tract infections in the Nilgiris district, South India.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Description of extraintestinal pathogenicIranian journal of microbiology · 2023Article
- Correlation of biofilm formation, virulence factors, and phylogenetic groups amongJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Review
- Genomics and pathotypes of the many faces of Escherichia coli.FEMS microbiology reviews · 2022Article
- Article
- Differences of virulence factors, and antimicrobial susceptibility according to phylogenetic group in uropathogenic Escherichia coli strains isolated from Korean patients.Annals of clinical microbiology and antimicrobials · 2021Article
- Effects of lipid emulsions on the formation of Escherichia coli-Candida albicans mixed-species biofilms on PVC.Scientific reports · 2021Article
- Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum β-Lactamase inMicroorganisms · 2021Article
- Characterization ofInfection and drug resistance · 2021Article
- Biofilm Formation amongMicroorganisms · 2020Article
- Relationship between Virulence and Resistance among Gram-Negative Bacteria.Antibiotics (Basel, Switzerland) · 2020Review
- Characterization of native Escherichia coli populations from bovine vagina of healthy heifers and cows with postpartum uterine disease.PloS one · 2020Article
- Virulence factors of uropathogenic Escherichia coli (UPEC) and correlation with antimicrobial resistance.BMC microbiology · 2019Article
- Human Bacterial Repertoire of the Urinary Tract: a Potential Paradigm Shift.Journal of clinical microbiology · 2019Review
- Comparative Study Of Genetic Diversity, Virulence Genotype, Biofilm Formation And Antimicrobial Resistance Of UropathogenicInfection and drug resistance · 2019Article
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9 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The present work set out to search for a virulence repertoire distinctive for Escherichia coli causing primitive acute pyelonephritis (APN). To this end, the virulence potential of 18 E. coli APN strains was genotypically and phenotypically assessed, comparatively with 19 strains causing recurrent cystitis (RC), and 16 clinically not significant (control, CO) strains. Most of the strains belong to phylogenetic group B1 (69.8%; p<0.01), and APN strains showed unique features, which are the presence of phylogroup A, and the absence of phylogroup B2 and non-typeable strains. Overall, the most dominant virulence factor genes (VFGs) were ecpA and fyuA (92.4 and 86.7%, respectively; p<0.05), and the mean number of VFGs was significantly higher in uropathogenic strains. Particularly, papAH and malX were exclusive for uropathogenic strains. APN and RC strains showed a significantly higher prevalence of fyuA, usp, and malX than of CO strains. Compared to RC strains, APN ones showed a higher prevalence of iha, but a lower prevalence of iroN, cnf1, and kpsMT-II. Hierarchical cluster analysis showed a higher proportion of two gene clusters (malX and usp, and fyuA and ecpA) were detected in the APN and RC groups than in CO, whereas iutA and iha clusters were detected more frequently in APN strains. The motility level did not differ among the study-groups and phylogroups considered, although a higher proportion of swarming strains was observed in APN strains. Antibiotic-resistance rates were generally low except for ampicillin (37.7%), and were not associated with specific study- or phylogenetic groups. APN and RC strains produced more biofilm than CO strains. In APN strains, iha was associated with higher biofilm biomass formation, whereas iroN and KpSMT-K1 were associated with a lower amount of biofilm biomass. Further work is needed to grasp the virulence and fitness mechanisms adopted by E. coli causing APN, and hence develop new therapeutic and prophylactic approaches.
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