ArticleMolecules (Basel, Switzerland)2018
Determination of Ten Macrolide Drugs in Environmental Water Using Molecularly Imprinted Solid-Phase Extraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- Development of an HPLC method for the simultaneous determination of azithromycin, clarithromycin, and erythromycin in wastewater.RSC advances · 2025Article
- Computational and Experimental Comparison of Molecularly Imprinted Polymers Prepared by Different Functional Monomers-Quantitative Parameters Defined Based on Molecular Dynamics Simulation.Molecules (Basel, Switzerland) · 2024Article
- Recent Advances of Biosensors for Detection of Multiple Antibiotics.Biosensors · 2023Review
- Recent Advances in Molecularly Imprinted Polymers for Antibiotic Analysis.Molecules (Basel, Switzerland) · 2023Review
- Recent molecularly imprinted polymers applications in bioanalysis.Chemicke zvesti · 2023Review
- Recent Advances and Perspectives on the Sources and Detection of Antibiotics in Aquatic Environments.Journal of analytical methods in chemistry · 2022Review
- Midecamycin Is Inactivated by Several Different Sugar Moieties at Its Inactivation Site.International journal of molecular sciences · 2021Article
- Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials.Molecules (Basel, Switzerland) · 2021Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the extensive application of antibiotics in livestock, their contamination of the aquatic environment has received more attention. Molecularly imprinted polymer (MIP), as an eco-friendly and durable solid-phase extraction material, has shown great potential for the separation and enrichment of antibiotics in water. This study aims at developing a practical and economical method based on molecularly imprinted solid phase extraction (MISPE) combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for simultaneously detecting ten macrolide drugs in different sources of water samples. The MIP was synthesized by bulk polymerization using tylosin as the template and methacrylic acid as the functional monomer. The MIP exhibited a favorable load-bearing capacity for water (>90 mL), which is more than triple that of non-molecularly imprinted polymers (NIP). The mean recoveries of macrolides at four spiked concentration levels (limit of quantification, 40, 100, and 400 ng/L) were 62.6⁻100.9%, with intra-day and inter-day relative standard deviations below 12.6%. The limit of detection and limit of quantification were 1.0⁻15.0 ng/L and 3.0⁻40.0 ng/L, respectively. Finally, the proposed method was successfully applied to the analysis of real water samples.
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