Evidence map›Paper›PMID 29757903›Full record

ReviewTransplantation2018

Contemporary Strategies and Barriers to Transplantation Tolerance.

Brian Ezekian, Paul M Schroder, Kyle Freischlag, Janghoon Yoon, Jean Kwun, Stuart J Knechtle

Abstract readReview
In one paragraph

Review in Transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
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  10. Acute murine cytomegalovirus disrupts established transplantation tolerance and causes recipient allo-sensitization.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  11. Review
  12. Apoptotic Donor Cells in Transplantation.Frontiers in immunology · 2021
    Review
  13. Review
  14. Article
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  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brian EzekianDuke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC.
Paul M SchroderDuke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC.
Kyle FreischlagDuke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC.
Janghoon YoonDuke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC.
Jean KwunDuke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC.
Stuart J KnechtleDuke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, NC.

Funding

Transplant Tolerance in Non-Human PrimatesU19AI051731 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI ADAMS, ANDREW B · 2002 to 2022
$54.1M
The Risks and Opportunities of Homeostatic RepopulationU19AI131471 · NIAID · DUKE UNIVERSITY · PI Andrew Serghios Barbas · 2017 to 2026
$30.4M
NIAID NIH HHS U19 AI051731NIAID NIH HHS U19 AI131471
6 · The paper itself

Abstract

The purpose of this review is to discuss immunologic tolerance as it applies to solid organ transplantation and to identify barriers that hinder the achievement of this long-term goal. First, the definition of tolerance and an introduction of mechanisms by which tolerance exists or can be achieved will be discussed. Next, a review of contemporary attempts at achieving transplant tolerance will be described. Finally, a discussion of the humoral barriers to transplantation tolerance and potential ways to overcome these barriers will be presented.

Indexed as

AnimalsB-LymphocytesCD4-Positive T-LymphocytesChimerismDendritic CellsGraft RejectionHumansImmunosuppression TherapyMacrophagesMesenchymal Stem CellsOrgan TransplantationThymus GlandT-Lymphocytes, RegulatoryTransplantation Tolerance

Identifiers

PMID29757903
PMCPMC6059978

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.