Evidence map›Paper›PMID 29757202›Full record

ArticleViruses2018

Genome Sequences of Akhmeta Virus, an Early Divergent Old World Orthopoxvirus.

Jinxin Gao, Crystal Gigante, Ekaterine Khmaladze, Pengbo Liu, Shiyuyun Tang, Kimberly Wilkins, Kun Zhao, Whitni Davidson, Yoshinori Nakazawa, Giorgi Maghlakelidze and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Pharmacological Agents with Antiviral Activity against Monkeypox Infection.International journal of molecular sciences · 2022
    Review
  10. Review
  11. Monkeypox virus: The changing facets of a zoonotic pathogen.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2022
    Review
  12. Article
  13. Article
  14. Exportation of Monkeypox Virus From the African Continent.The Journal of infectious diseases · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Jinxin GaoPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. jgao2@cdc.gov.
Crystal GigantePoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. lzu1@cdc.gov.ORCID 0000-0002-2169-7156
Ekaterine KhmaladzeLaboratory of Molecular Epidemiology, National Center for Disease Control and Public Health of Georgia, 9 M. Asatiani Street, Tbilisi 0177, Georgia. e.khmaladze@ncdc.ge.
Pengbo LiuPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. pliu0628@gmail.com.
Shiyuyun TangPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. Tangshi06@gmail.com.
Kimberly WilkinsPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. ibx4@cdc.gov.
Kun ZhaoPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. vzt5@cdc.gov.
Whitni DavidsonPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. wfd6@cdc.gov.
Yoshinori NakazawaPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. inp7@cdc.gov.
Giorgi MaghlakelidzeDivision of Global Health Protection (DGHP), Center for Global Health, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. kuo9@cdc.gov.
Marika GeleishviliDivision of Global Health Protection (DGHP), Center for Global Health, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. ivu9@cdc.gov.
Maka KokhreidzeLaboratory of the Ministry of Agriculture of Georgia (LMA), Animal Disease Diagnostic Department, 49 Vaso Godziashvilis Street, Tbilisi 0159, Georgia. maka.kokhreidze@lma.gov.ge.
Darin S CarrollPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. DCarroll@cdc.gov.
Ginny EmersonPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. GEmerson@cdc.gov.
Yu LiPoxvirus and Rabies Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers of Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA. YuLi@cdc.gov.
National Center for Emerging and Zoonotic Infectious Diseases · USCenters for Disease Control and Prevention · USMinistry of Agriculture · IDNational Center for Disease Control and Public Health · GE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Annotated whole genome sequences of three isolates of the Akhmeta virus (AKMV), a novel species of orthopoxvirus (OPXV), isolated from the Akhmeta and Vani regions of the country Georgia, are presented and discussed. The AKMV genome is similar in genomic content and structure to that of the cowpox virus (CPXV), but a lower sequence identity was found between AKMV and Old World OPXVs than between other known species of Old World OPXVs. Phylogenetic analysis showed that AKMV diverged prior to other Old World OPXV. AKMV isolates formed a monophyletic clade in the OPXV phylogeny, yet the sequence variability between AKMV isolates was higher than between the monkeypox virus strains in the Congo basin and West Africa. An AKMV isolate from Vani contained approximately six kb sequence in the left terminal region that shared a higher similarity with CPXV than with other AKMV isolates, whereas the rest of the genome was most similar to AKMV, suggesting recombination between AKMV and CPXV in a region containing several host range and virulence genes.

Indexed as

Genome, ViralAfrica, WesternCongoCowpox virusDNA, ViralMonkeypox virusOrthopoxvirusPhenotypePhylogenyRecombination, GeneticSequence Analysis, DNAVariola virusWhole Genome SequencingDNA, ViralAkhmeta viruscowpox virusorthopoxvirusrecombination

Identifiers

PMID29757202
PMCPMC5977245
OpenAlexW2799959724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.