ArticleJournal of feline medicine and surgery2019
Evaluation of the efficacy of an appeasing pheromone diffuser product vs placebo for management of feline aggression in multi-cat households: a pilot study.
Article in Journal of feline medicine and surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- 2024 AAFP intercat tension guidelines: recognition, prevention and management.Journal of feline medicine and surgery · 2024Guideline
- Effects of a synthetic feline facial pheromone analogue (F3, FeliwayBMC veterinary research · 2026Article
- Enhanced environmental acclimation of cats using an innovative passive diffuser of the facial-marking pheromone (F3).Journal of feline medicine and surgery · 2026Article
- Environmental Exposure to the Common Trunk of Mammalian Appeasing Pheromone Modulates Social Behavior and Reduces Fight Wounds in Male Mice.Animals : an open access journal from MDPI · 2025Article
- Chemosensory Receptors in Vertebrates: Structure and Computational Modeling Insights.International journal of molecular sciences · 2025Review
- Infrared Thermography and Physiological Variables as Methods for Recognizing Fear in Domestic Cats (Veterinary sciences · 2025Article
- Helping Rabbits Cope with Veterinary Acts and Vaccine-Related Stress: The Effects of the Rabbit Appeasing Pheromone (RAP).Animals : an open access journal from MDPI · 2024Article
- Cutaneous application of SecurePig® FLASH, a Pig appeasing pheromone analogue, facilitates adaptation and manages social behavior during feeding in semi-extensive conditions.Porcine health management · 2024Article
- Efficacy of a pheromone-impregnated collar in controlling feline problem behaviors, and an assessment of adverse events associated with collar use.Frontiers in veterinary science · 2024Article
- Effect of wither application of an analogue of pig appeasing pheromone on encounters between unfamiliar mini-pigs.Porcine health management · 2022Article
- Effect of a synthetic feline facial pheromone product on stress during transport in domestic cats: a randomised controlled pilot study.Journal of feline medicine and surgery · 2022Article
- Group Reunion in Zoo European Wildcats Using Cat Appeasing Pheromone (CAP) and Gradual Release of the Animals in the Exhibit-A Case Study.Animals : an open access journal from MDPI · 2022Article
- Are multi-cat homes more stressful? A critical review of the evidence associated with cat group size and wellbeing.Journal of feline medicine and surgery · 2022Review
- Control of felinine-derived malodor in cat litter.Journal of feline medicine and surgery · 2022Article
- Conspecific and Human Sociality in the Domestic Cat: Consideration of Proximate Mechanisms, Human Selection and Implications for Cat Welfare.Animals : an open access journal from MDPI · 2022Review
- Dealing With Stress in Cats: What Is New About the Olfactory Strategy?Frontiers in veterinary science · 2022Review
- Appeasing Pheromones for the Management of Stress and Aggression during Conservation of Wild Canids: Could the Solution Be Right under Our Nose?Animals : an open access journal from MDPI · 2021Review
- Conflict and affiliative behavior frequency between cats in multi-cat households: a survey-based study.Journal of feline medicine and surgery · 2020Article
- The Major Cat Allergen Fel d 1 Binds Steroid and Fatty Acid Semiochemicals: A Combined In Silico and In Vitro Study.International journal of molecular sciences · 2020Article
- Cats vs. Dogs: The Efficacy of Feliway FriendsFrontiers in veterinary science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAggression and social tension among housemate cats is common and puts cats at risk of injury or relinquishment. The aim of this study was to evaluate the effectiveness of a new pheromone product in reducing aggression between housemate cats.
methodsA new pheromone product (Feliway Friends) containing a proprietary cat-appeasing pheromone was evaluated for efficacy in reducing aggression between housemate cats via a randomized, double-blind, placebo-controlled pilot trial of 45 multi-cat households (pheromone [n = 20], placebo [n = 25]) reporting aggression for at least 2 weeks. Each household had 2-5 cats. Participants attended an educational training meeting on day (D) -7 and the veterinary behaviorist described behaviors to be monitored for 7 weeks using the Oakland Feline Social Interaction Scale (OFSIS), which assessed the frequency and intensity of 12 representative aggressive interactions. Participants were also provided with instructions for handling aggressive events, including classical conditioning, redirection by positive reinforcement and not punishing or startling the cat for aggressive displays. Punishment techniques were strongly discouraged. Plug-in diffusers with the pheromone product or placebo were utilized from D0-D28. Participants completed a daily diary of aggressive events and weekly OFSIS assessments through to D42.
resultsEvolution of the OFSIS-Aggression score according to treatment group in the full analysis set population revealed a significant effect on time and treatment group. The OFSIS-Aggression score decreased over time from D0-D28 in both groups (time factor P = 0.0001) with a significant difference in favor of the verum P = 0.06); similar results were found considering the D0-D42 period (time factor P = 0.0001 [D0] and P = 0.04 [D42]). CONCLUSIONS AND RELEVANCE: The OFSIS provided a quantifiable measure of the frequency and intensity of 12 intercat interactions reflecting conflict between cats. The cat-appeasing pheromone is a promising treatment for the management of aggression between housemate cats in multi-cat households.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.