ArticleJournal of women's health (2002)2018
Gut Microbiota Composition in Mid-Pregnancy Is Associated with Gestational Weight Gain but Not Prepregnancy Body Mass Index.
Article in Journal of women's health (2002), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Dietary pulse prebiotic fibre intake in a rat obese pregnancy model alters maternal caecal microbiome and protects against steatosis in newly weaned offspring.Journal of nutritional science · 2026Article
- Gut microbiota changes in patients with hypertensive disorders and gestational diabetes in early pregnancy: a prospective cohort study.BMC pregnancy and childbirth · 2025Article
- Analysis of the microbiota of pregnant women in relation to weight gain during pregnancy - a pilot study.Frontiers in cellular and infection microbiology · 2025Article
- Characterization of newborn gut microbiota according to the pre-gestational maternal nutritional status and delivery mode.Archives of gynecology and obstetrics · 2024Article
- Maternal Body Mass Index Associates with Prenatal Characteristics and Fecal Microbial Communities.Nutrients · 2024Observational
- Article
- Parity modulates impact of BMI and gestational weight gain on gut microbiota in human pregnancy.Gut microbes · 2023Article
- Modulation of gut microbiota by diet and probiotics: potential approaches to prevent gestational diabetes mellitus.Gut microbiome (Cambridge, England) · 2023Review
- The Gut Microbiome During Pregnancy.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- Intestinal flora and linear growth in children.Frontiers in pediatrics · 2023Review
- Changes in the Gut Microbiome and Pathologies in Pregnancy.International journal of environmental research and public health · 2022Review
- Review
- Exploration of Diet Quality by Obesity Severity in Association with Gestational Weight Gain and Distal Gut Microbiota in Pregnant African American Women: Opportunities for Intervention.Maternal and child health journal · 2022Article
- Recent research on the effect of preeclampsia on maternal-infant intestinal flora interactions.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Review
- Sick Individuals and Sick (Microbial) Populations: Challenges in Epidemiology and the Microbiome.Annual review of public health · 2020Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregnancy is a time of numerous hormonal, metabolic, and immunological changes for both the mother and the fetus. Furthermore, maternal gut microbiota composition (GMC) is altered during pregnancy. One major factor affecting GMC in pregnant and nonpregnant populations is obesity. The aim was to analyze associations between maternal overweight/obesity, as well as gestational weight gain (GWG) and GMC. Moreover, the modifying effect of depression and anxiety symptom scores on weight and GMC were investigated.
methodsStudy included 46 women from the FinnBrain Birth Cohort study, of which 36 were normal weight, and 11 overweight or obese according to their prepregnancy body mass index (BMI). Stool samples were collected in gestational week 24, and the GMC was sequenced with Illumina MiSeq approach. Hierarchical clustering was executed to illuminate group formation according to the GMC. The population was divided according to Firmicutes and Bacteroidetes dominance. Symptoms of depression, general anxiety, and pregnancy-related anxiety were measured by using standardized questionnaires.
resultsExcessive GWG was associated with distinct GMC in mid-pregnancy as measured by hierarchical clustering and grouping according to Firmicutes or Bacteroidetes dominance, with Bacteroidetes being prominent and Firmicutes being less prominent in the GMC among those with increased GWG. Reduced alpha diversity was observed among the Bacteroidetes-dominated subjects. There were no zero-order effects between the abundances of bacterial genera or phyla, alpha or beta diversity, and prepregnancy BMI or GWG.
conclusionBacteroidetes-dominated GMC in mid-pregnancy is associated with increased GWG and reduced alpha diversity.
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