ArticleChemistry (Weinheim an der Bergstrasse, Germany)2018
Existence of Diverse Modifications in Small-RNA Species Composed of 16-28 Nucleotides.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Emerging roles of RNA N4-acetylcytidine modification in reproductive health.Protein & cell · 2025Review
- [Advances in mapping analysis of ribonucleic acid modifications through sequencing].Se pu = Chinese journal of chromatography · 2024Review
- SWAMNA: a comprehensive platform for analysis of nucleic acid modifications.Chemical communications (Cambridge, England) · 2023Article
- Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure.Environmental toxicology and pharmacology · 2023Article
- Change of Heart: the Epitranscriptome of Small Non-coding RNAs in Heart Failure.Current heart failure reports · 2022Review
- Formation and removal of 1,N6-dimethyladenosine in mammalian transfer RNA.Nucleic acids research · 2022Article
- RNA marker modifications reveal the necessity for rigorous preparation protocols to avoid artifacts in epitranscriptomic analysis.Nucleic acids research · 2022Article
- N-6-Methyladenosine in Vasoactive microRNAs during Hypoxia; A Novel Role for METTL4.International journal of molecular sciences · 2022Article
- The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells.RNA biology · 2022Article
- Chemical tagging for sensitive determination of uridine modifications in RNA.Chemical science · 2020Article
- Review
- The epitranscriptome: tools to study, manipulate, and exploit RNA modifications.Cardiovascular research · 2019Article
- Nucleotide resolution sequencing of N4-acetylcytidine in RNA.Methods in enzymology · 2019Article
- Functional Interplay between Small Non-Coding RNAs and RNA Modification in the Brain.Non-coding RNA · 2018Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA contains diverse modifications that exert an important influence in a variety of cellular processes. So far, more than 150 modifications have been identified in various RNA species, mainly in ribosomal RNA (rRNA), transfer RNA (tRNA), and messenger RNA (mRNA). In contrast to rRNA, tRNA, and mRNA, the known modifications in small RNA species have been primarily limited to 2'-O-ribose methylation in plants and inosine in mammals. The methylation of small RNAs in mammals is still unclear. Current methods widely used in the characterization of small RNAs are mainly based on the strategy of nucleic acid hybridization and sequencing, which cannot characterize modifications in small RNAs. Herein, we have systematically investigated modifications in small RNAs composed of 16-28 nucleotides (nt) by establishing an effective isolation and neutral enzymatic digestion of small RNAs in combination with liquid chromatography/electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). This method allowed us to simultaneously detect 57 different types of nucleoside modification. By using this approach, we revealed 24 modifications in small RNAs comprising 16-28 nt from human cells. In addition, we found that the obesity-associated protein (FTO) may demethylate N
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