ArticleThe Journal of physiology2018
Sex differences in diaphragmatic fatigue: the cardiovascular response to inspiratory resistance.
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 68 citations in OpenAlex.
- Influence of an inspiratory muscle fatigue protocol on older adults on respiratory muscle strength, muscle oxygen saturation, and functional capacity: a randomized controlled trial.BMC geriatrics · 2024Trial
- Influence of an inspiratory muscle fatigue protocol on healthy youths on respiratory muscle strength, vertical jump performance and muscle oxygen saturation: a randomized controlled trial.Journal of translational medicine · 2024Trial
- Current limits for flowmeter resistance in metabolic carts can negatively affect exercise performance.Physiological reports · 2021Trial
- The influence of mouth pressure on the cardiovascular response during inspiratory muscle loading at a constant transdiaphragmatic pressure.European journal of applied physiology · 2026Article
- Stimulus-dependent sex differences in dyspnoea: Mechanical loading vs. hypercapnia.Experimental physiology · 2026Article
- Ageing exacerbates the adverse effects of respiratory muscle fatigue on vascular function, locomotor muscle fatigue and exercise performance in males.Experimental physiology · 2026Article
- Influence of a diaphragmatic fatigue protocol in healthy male population on muscle strength, respiratory function and exercise capacity: A randomized clinical trial.Journal of exercise science and fitness · 2025Article
- The hyperaemic and metaboreflex response of the diaphragm during fatiguing diaphragmatic work in humans.The Journal of physiology · 2025Article
- Cerebral haemodynamic responses to inspiratory muscle work.Experimental physiology · 2025Article
- Inspiratory Muscle Training Included in Therapeutic and Training Regimens for Middle-Distance Runners.Journal of clinical medicine · 2025Article
- Predictive Threshold Value of the Breathing Reserve for the Decline in Cardiorespiratory Fitness Among the Healthy Middle-Aged Population.Journal of cardiovascular development and disease · 2025Article
- Article
- The Effectiveness and Validity of Inspiratory Muscle Training in the Training Process of Disabled Swimmers.Journal of clinical medicine · 2024Article
- Influence of an inspiratory muscle fatigue protocol on older adults on respiratory muscle strength and heart rate variability. A randomized controlled trial.Frontiers in neuroscience · 2024Article
- Influence of an inspiratory muscle fatigue protocol on healthy youths on respiratory muscle strength and heart rate variability. A randomized controlled trial.Frontiers in physiology · 2024Article
- The effect of inspiratory muscle training and detraining on the respiratory metaboreflex.Experimental physiology · 2023Article
- Effects of hypoxia on exercise-induced diaphragm fatigue in healthy males and females.Physiological reports · 2023Article
- A short course of high-resistance, low-volume breathing exercise extends respiratory endurance and blunts cardiovascular responsiveness to constant load respiratory testing in healthy young adults.Respiratory physiology & neurobiology · 2023Article
- Voluntary activation of the diaphragm after inspiratory pressure threshold loading.Physiological reports · 2023Article
- Sex differences in blood pressure and inactive limb blood flow responses during dynamic leg exercise with increased inspiratory muscle work.Nagoya journal of medical science · 2022Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsDiaphragmatic fatigue (DF) elicits a sympathetically mediated metaboreflex resulting in increased heart rate, blood pressure and limb vascular resistance. Women may be more resistant to DF compared to men, and therefore it was hypothesised that women would experience an attenuated inspiratory muscle metaboreflex during inspiratory pressure-threshold loading (PTL) performed to task failure. At the time of PTL task failure, the severity of DF was not different between sexes; however, inspiratory muscle endurance time was significantly longer in women than in men. For a given cumulative diaphragmatic force output, the severity of DF was less in women than in men. Women exhibited a blunted cardiovascular response to inspiratory resistance (i.e. metaboreflex) that may have implications for exercise tolerance. ABSTRACT: Diaphragmatic fatigue (DF) elicits reflexive increases in sympathetic vasomotor outflow (i.e. metaboreflex). There is some evidence suggesting women may be more resistant to DF compared to men, and therefore may experience an attenuated inspiratory muscle metaboreflex. To this end, we sought to examine the cardiovascular response to inspiratory resistance in healthy young men (n = 9, age = 24 ± 3 years) and women (n = 9, age = 24 ± 3 years). Subjects performed isocapnic inspiratory pressure-threshold loading (PTL, 60% maximal inspiratory mouth pressure) to task failure. Diaphragmatic fatigue was assessed by measuring transdiaphragmatic twitch pressure (P
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