Evidence map›Paper›PMID 29756522›Full record

GuidelineJournal of neurotrauma2018

Pre-Clinical Testing of Therapies for Traumatic Brain Injury.

Douglas S DeWitt, Bridget E Hawkins, C Edward Dixon, Patrick M Kochanek, William Armstead, Cameron R Bass, Helen M Bramlett, Andras Buki, W Dalton Dietrich, Adam R Ferguson and 18 more

Open access · greenAbstract readConsensus StatementGuideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Journal of neurotrauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Revisiting the critical roles of reactive microglia in traumatic brain injury.International journal of surgery (London, England) · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. ApoE Mimetic Peptides as Therapy for Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  17. Increasing Rigor of Preclinical Research to Maximize Opportunities for Translation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  18. Review
  19. Article
  20. Aberrant cortical spine dynamics after concussive injury are reversed by integrated stress response inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 4 countries.

Douglas S DeWitt1 Department of Anesthesiology, University of Texas Medical Branch , Galveston, Texas.
Bridget E Hawkins1 Department of Anesthesiology, University of Texas Medical Branch , Galveston, Texas.
C Edward Dixon2 Department of Neurological Surgery, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
Patrick M Kochanek3 Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania.
William Armstead4 Department of Anesthesiology and Critical Care, University of Pennsylvania , Philadelphia, Pennsylvania.
Cameron R Bass5 Department of Biomedical Engineering, Duke University , Durham, North Carolina.
Helen M Bramlett6 Department of Neurological Surgery, The Miami Project to Cure Paralysis , Miami, Florida.
Andras Buki7 Department of Neurosurgery, Medical University of Pécs , Pécs, Hungary .
W Dalton Dietrich8 The Miami Project to Cure Paralysis, Leonard M. Miller School of Medicine, University of Miami , Miami, Florida.
Adam R Ferguson9 Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California , San Francisco (UCSF), San Francisco, California.
Edward D Hall10 Spinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky Medical Center , Lexington, Kentucky.
Ronald L Hayes11 University of Florida, Virginia Commonwealth University, Banyan Biomarkers, Inc. , Alachua, Florida.
Sidney R Hinds12 United States Army Medical Research and Materiel Command , Fort Detrick, Maryland.
Michelle C LaPlaca13 Georgia Institute of Technology/Emory University , Atlanta, Georgia .
Joseph B Long14 Blast-Induced Neurotrauma Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research , Silver Spring, Maryland.
David F Meaney15 Department of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania.
Stefania Mondello16 Department of Neurosciences, University of Messina , Via Consolare Valeria, Messina, Italy .
Linda J Noble-Haeusslein17 Departments of Neurology and Psychology, Dell Medical School, The University of Texas at Austin , Austin, Texas.
Samuel M Poloyac18 Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy , Pittsburgh, Pennsylvania.
Donald S Prough1 Department of Anesthesiology, University of Texas Medical Branch , Galveston, Texas.
Claudia S Robertson19 Department of Neurosurgery, Baylor College of Medicine , Houston, Texas.
Kathryn E Saatman20 Spinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky , Lexington, Kentucky.
Sandy R Shultz21 Department of Medicine, Melbourne Brain Center, The University of Melbourne , Parkville, Victoria, Australia .
Deborah A Shear22 Brain Trauma Neuroprotection Program, Walter Reed Army Institute of Research , Silver Spring, Maryland.
Douglas H Smith23 Department of Neurosurgery, University of Pennsylvania , Philadelphia, Pennsylvania.
Alex B Valadka24 Department of Neurosurgery, Virginia Commonwealth University School of Medicine , Richmond, Virginia.
Pamela VandeVord25 Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University , Blacksburg, Virginia.
Liying Zhang26 Department of Biomedical Engineering, Wayne State University , Detroit, Michigan.
California University of Pennsylvania · USThe University of Texas Medical Branch at Galveston · USUniversity of Pittsburgh · USUniversity of Kentucky · USWalter Reed Army Institute of Research · USBanyan Biomarkers (United States) · USBaylor College of Medicine · USDuke University · USGeorgia Institute of Technology · USJackson Health System · USThe University of Melbourne · AUThe University of Texas at Austin · USUnited States Army Medical Research and Development Command · USUniversity of California, San Francisco · USUniversity of Messina · ITUniversity of Miami · USUniversity of Pecs · HUVirginia Commonwealth University · USVirginia Tech · USWayne State University · US

Funding

Neuropathological Characterization of 'CTE'R01NS094003 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Douglas Hamilton Smith, William Stewart · 2016 to 2026
$5.1M
Detection and Mechanisms of Mild Traumatic Brain InjuryR01NS092398 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SMITH, DOUGLAS HAMILTON · 2015 to 2019
$1.9M
NINDS NIH HHS R01 NS092398NINDS NIH HHS R01 NS094003
6 · The paper itself

Abstract

Despite the large number of promising neuroprotective agents identified in experimental traumatic brain injury (TBI) studies, none has yet shown meaningful improvements in long-term outcome in clinical trials. To develop recommendations and guidelines for pre-clinical testing of pharmacological or biological therapies for TBI, the Moody Project for Translational Traumatic Brain Injury Research hosted a symposium attended by investigators with extensive experience in pre-clinical TBI testing. The symposium participants discussed issues related to pre-clinical TBI testing including experimental models, therapy and outcome selection, study design, data analysis, and dissemination. Consensus recommendations included the creation of a manual of standard operating procedures with sufficiently detailed descriptions of modeling and outcome measurement procedures to permit replication. The importance of the selection of clinically relevant outcome variables, especially related to behavior testing, was noted. Considering the heterogeneous nature of human TBI, evidence of therapeutic efficacy in multiple, diverse (e.g., diffuse vs. focused) rodent models and a species with a gyrencephalic brain prior to clinical testing was encouraged. Basing drug doses, times, and routes of administration on pharmacokinetic and pharmacodynamic data in the test species was recommended. Symposium participants agreed that the publication of negative results would reduce costly and unnecessary duplication of unsuccessful experiments. Although some of the recommendations are more relevant to multi-center, multi-investigator collaborations, most are applicable to pre-clinical therapy testing in general. The goal of these consensus guidelines is to increase the likelihood that therapies that improve outcomes in pre-clinical studies will also improve outcomes in TBI patients.

Indexed as

Disease Models, AnimalAnimalsBrain Injuries, TraumaticHumansguidelinespre-clinicaltraumatic brain injury

Identifiers

PMID29756522
PMCPMC8349722
OpenAlexW2799544839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.