ArticleJournal of evidence-based integrative medicine
Anti-Hyperglycemic and Anti-Inflammatory Activities of Polyphenolic-Rich Extract of Syzygium cumini Linn Leaves in Alloxan-Induced Diabetic Rats.
Article in Journal of evidence-based integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Antioxidative and Anti-inflammatory Effects of Plant-derived Hypoglycemic Medicines: AnCurrent topics in medicinal chemistry · 2024Pooled it
- Efficacy and Safety ofFoods (Basel, Switzerland) · 2026Review
- Neuroprotective effect ofToxicology reports · 2024Article
- Antioxidant, antidiabetic, and anti-inflammatory activities of flavonoid-rich fractions ofHeliyon · 2024Article
- Nephroprotective Effect ofACS omega · 2024Article
- Mitigation of Diabetes Mellitus UsingJournal of diabetes research · 2024Article
- Phytochemical Profile, Biological Properties, and Food Applications of the Medicinal PlantFoods (Basel, Switzerland) · 2022Review
- Antidiabetic Activity of Elephant Grass (Cenchrus Purpureus (Schumach.) Morrone)Frontiers in pharmacology · 2022Article
- Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies.Foods (Basel, Switzerland) · 2021Review
- Article
- Article
- Effect ofThe Journal of international medical research · 2020Article
- Antidiabetic activity of watermelon (Journal of diabetes and metabolic disorders · 2020Article
- Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review.Frontiers in bioengineering and biotechnology · 2020Review
- Antihyperglycaemia and related gene expressions of aqueous extract ofPharmaceutical biology · 2019Article
- An ethnobotanical survey of medicinal plants used for diabetes treatment in Rabat, Morocco.Heliyon · 2019Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, anti-hyperglycemic and anti-inflammatory activities of polyphenolic-rich extract of Syzygium cumini leaves in alloxan-induced diabetic rats were determined. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg body weight) in female Wistar rats. The rats were orally administered with 400 mg/kg free phenol, 400 mg/kg bound phenol, and 5 mg/kg metformin, respectively. On the 14th day of oral administration, the animals were sacrificed, anti-hyperglycemic and anti-inflammatory were assessed. Fasting blood glucose and glycated hemoglobin levels; homeostasis model assessment-insulin resistance scores, lipid peroxidation concentration, glucose-6-phosphatase activity, and all concentrations of anti-inflammatory studied in alloxan-induced diabetic rats were significantly ( P < .05) reduced with the administration of polyphenolic-rich extract of Syzygium cumini leaves. Also there was significant ( P < .05) increase in glycogen and insulin concentrations, pancreatic β-cell scores, antioxidant enzymes and hexokinase activities, as well as glucose transporter levels in diabetic animals administered with polyphenolic-rich extract of S cumini leaves. The results indicate that S cumini leaves possess anti-hyperglycemic and anti-inflammatory activities.
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