Evidence map›Paper›PMID 29756333›Full record

GuidelinePain practice : the official journal of World Institute of Pain2019

Safe Use of Epidural Corticosteroid Injections: Recommendations of the WIP Benelux Work Group.

Koen Van Boxem, Mienke Rijsdijk, Guy Hans, Jasper de Jong, Jan Willem Kallewaard, Kris Vissers, Maarten van Kleef, James P Rathmell, Jan Van Zundert

Registry-linked trialOpen access · hybridAbstract readPractice GuidelineReview
In one paragraph

Guideline in Pain practice : the official journal of World Institute of Pain, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06956664 (Comparative Efficacy of Physiotherapeutic Exercise Regimens Implemented After Caudal Epidural Steroid Injection), which is not on this map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06956664 narecruitingnot on this mapstarted 2025, after this paper: background citation

Comparative Efficacy of Physiotherapeutic Exercise Regimens Implemented After Caudal Epidural Steroid Injection

TypeinterventionalSponsorÇankırı Karatekin UniversityRan2025 to 2026Enrolled42ConditionsIntervertebral Disc Displacement, Low Back Pain, RadiculopathyArmsConventional Physiotherapy, Aerobic Exercise Programme, Core-Stabilization Exercise Programme
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 98 citations in OpenAlex.

  1. Trial
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  4. Article
  5. Observational
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  10. Review
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  15. 11. Cervicogenic headache and occipital neuralgia.Pain practice : the official journal of World Institute of Pain · 2025
    Review
  16. 8. Herpes zoster and post herpetic neuralgia.Pain practice : the official journal of World Institute of Pain · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Koen Van BoxemDepartment of Anesthesiology, Critical Care and Multidisciplinary Pain Center, Ziekenhuis Oost-Limburg, Genk/Lanaken, Belgium.
Mienke RijsdijkPain Clinic, Department of Anesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Guy HansMultidisciplinary Pain Center, Antwerp University Hospital, Edegem, Belgium.
Jasper de JongDepartment of Pain Management, Westfriesgasthuis, Hoorn, The Netherlands.
Jan Willem KallewaardDepartment of Anesthesiology and Pain Management, Rijnstate Ziekenhuis, Arnhem, The Netherlands.
Kris VissersDepartment of Anesthesiology, Pain and Palliative Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Maarten van KleefDepartment of Anesthesiology and Pain Management, University Medical Centre Maastricht, Maastricht, The Netherlands.
James P RathmellDepartment of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts, U.S.A.
Jan Van ZundertDepartment of Anesthesiology, Critical Care and Multidisciplinary Pain Center, Ziekenhuis Oost-Limburg, Genk/Lanaken, Belgium.
Ziekenhuis Oost-Limburg · BEMaastricht University Medical Centre · NLRadboud University Nijmegen · NLRijnstate Hospital · NLUniversity Medical Center Utrecht · NLUniversity of Antwerp · BEWestfriesgasthuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidural corticosteroid injections are used frequently worldwide in the treatment of radicular pain. Concerns have arisen involving rare major neurologic injuries after this treatment. Recommendations to prevent these complications have been published, but local implementation is not always feasible due to local circumstances, necessitating local recommendations based on literature review.

methodsA work group of 4 stakeholder pain societies in Belgium, The Netherlands, and Luxembourg (Benelux) has reviewed the literature involving neurological complications after epidural corticosteroid injections and possible safety measures to prevent these major neurologic injuries.

resultsTwenty-six considerations and recommendations were selected by the work group. These involve the use of imaging, injection equipment particulate and nonparticulate corticosteroids, epidural approach, and maximal volume to be injected.

conclusionRaising awareness about possible neurological complications and adoption of safety measures recommended by the work group aim at reducing the risks for these devastating events.

Indexed as

Adrenal Cortex HormonesBelgiumHumansInjections, EpiduralNetherlandsRadiculopathyAdrenal Cortex Hormonescomplicationscorticosteroiddexamethasoneepiduralsafe use

Identifiers

PMID29756333
PMCPMC7379698
OpenAlexW2803669141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.