Evidence map›Paper›PMID 29756275›Full record

ReviewAdvanced healthcare materials2018

Nitric Oxide-Releasing Macromolecular Scaffolds for Antibacterial Applications.

Lei Yang, Evan S Feura, Mona Jasmine R Ahonen, Mark H Schoenfisch

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lei YangDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Evan S FeuraDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Mona Jasmine R AhonenDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Mark H SchoenfischDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-2212-0658

Funding

Nitric oxide-releasing dendrimers for the treatment of periodontal diseaseR01DE025207 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHOENFISCH, MARK H · 2015 to 2019
$1.6M
NIDCR NIH HHS R01 DE025207
6 · The paper itself

Abstract

Exogenous nitric oxide (NO) represents an attractive antibacterial agent because of its ability to both disperse and directly kill bacterial biofilms while avoiding resistance. Due to the challenges associated with administering gaseous NO, NO-releasing macromolecular scaffolds are developed to facilitate NO delivery. This progress report describes the rational design and application of NO-releasing macromolecular scaffolds as antibacterial therapeutics. Special consideration is given to the role of the physicochemical properties of the NO storage vehicles on antibacterial or anti-biofilm activity.

Indexed as

Anti-Bacterial AgentsBiofilmsHumansLiposomesMacromolecular SubstancesMolecular WeightNanoparticlesNitratesNitric OxideNitric Oxide DonorsPolymersSurface PropertiesAnti-Bacterial AgentsLiposomesMacromolecular SubstancesNitratesNitric OxideNitric Oxide DonorsPolymersantibacterialbiofilmsmacromolecular scaffoldsnitric oxiderational designs

Identifiers

PMID29756275
PMCPMC6159924

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.