Evidence map›Paper›PMID 29756251›Full record

ArticleAmerican journal of hematology2018

Fixed Low-Dose Hydroxyurea for the Treatment of Adults with Sickle Cell Anemia in Nigeria.

Bamidele O Tayo, Titilola S Akingbola, Santosh L Saraf, Binal N Shah, Chinedu A Ezekekwu, Omowunmi Sonubi, Lewis L Hsu, Richard S Cooper, Victor R Gordeuk

Registry-linked trialAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hematology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02149537 (Risk Stratification for Clinical Severity of Sickle Cell Disease in Nigeria and Assessment of Efficacy and Safety During Treatment With Hydroxyurea), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02149537 phase4completednot on this map

Risk Stratification for Clinical Severity of Sickle Cell Disease in Nigeria and Assessment of Efficacy and Safety During Treatment With Hydroxyurea

TypeinterventionalSponsorLoyola UniversityRan2014 to 2022Enrolled53ConditionsSickle Cell Disease, Sickle Cell AnemiaArmshydroxyurea
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. New Therapeutic Options for the Treatment of Sickle Cell Disease.Mediterranean journal of hematology and infectious diseases · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bamidele O TayoDepartment of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, IL.ORCID http://orcid.org/0000-0002-2277-3958
Titilola S AkingbolaDepartment of Hematology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Santosh L SarafDivision of Hematology & Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL.ORCID http://orcid.org/0000-0002-8584-4194
Binal N ShahDivision of Hematology & Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL.
Chinedu A EzekekwuDepartment of Hematology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Omowunmi SonubiDepartment of Hematology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Lewis L HsuDivision of Pediatric Hematology-Oncology, Department of Pediatrics, University of Illinois at Chicago, Chicago, IL.
Richard S CooperDepartment of Public Health Sciences, Loyola University Chicago Stritch School of Medicine, Maywood, IL.
Victor R GordeukDivision of Hematology & Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL.

Funding

Doris Duke Charitable Foundation 2013140
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

fixed low doseHydroxyureasickle cell anemiasickle cell disease

Identifiers

PMID29756251
PMCPMC6235722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.