Evidence map›Paper›PMID 29756230›Full record

ArticleEchocardiography (Mount Kisco, N.Y.)2018

The relationship between pulmonary artery wedge pressure and pulmonary blood volume derived from contrast echocardiography: A proof-of-concept study.

Ken Monahan, Daniel Lenihan, Evan L Brittain, Linda Saliba, Robert N Piana, Leslie L Robison, Melissa M Hudson, Gregory T Armstrong

Abstract read
In one paragraph

Article in Echocardiography (Mount Kisco, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ken MonahanDivision of Cardiovascular Medicine, Vanderbilt Medical Center, Nashville, TN, USA.ORCID 0000-0002-1650-4647
Daniel LenihanDivision of Cardiovascular Medicine, Washington University in St Louis, St Louis, MO, USA.
Evan L BrittainDivision of Cardiovascular Medicine, Vanderbilt Medical Center, Nashville, TN, USA.
Linda SalibaDivision of Cardiovascular Medicine, Vanderbilt Medical Center, Nashville, TN, USA.
Robert N PianaDivision of Cardiovascular Medicine, Vanderbilt Medical Center, Nashville, TN, USA.
Leslie L RobisonDepartment of Epidemiology and Cancer Control, St Jude Children's, Research Hospital, Memphis, TN, USA.
Melissa M HudsonDepartment of Epidemiology and Cancer Control, St Jude Children's, Research Hospital, Memphis, TN, USA.
Gregory T ArmstrongDepartment of Epidemiology and Cancer Control, St Jude Children's, Research Hospital, Memphis, TN, USA.

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
The St. Jude Lifetime CohortU01CA195547 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI HUDSON, MELISSA M, NESS, KIRSTEN KIMBERLIE · 2015 to 2024
$14.9M
Lantheus Medical Imaging 11022NCI NIH HHS CA195547NCI NIH HHS CA21765NCI NIH HHS P30 CA021765NCI NIH HHS U01 CA195547
6 · The paper itself

Abstract

backgroundPulmonary transit time (PTT) obtained from contrast echocardiography is a marker of global cardiopulmonary function. Pulmonary blood volume (PBV), derived from PTT, may be a noninvasive surrogate for left-sided filling pressures, such as pulmonary artery wedge pressure (PAWP). We sought to assess the relationship between PBV obtained from contrast echocardiography and PAWP.

methodsParticipants were adult survivors of childhood cancer that had contrast echocardiography performed nearly simultaneously with right-heart catheterization. PTT was derived from time-intensity curves of contrast passage through the right ventricle (RV) and left atrium (LA). PBV relative to overall stroke volume (rPBV) was estimated from the product of PTT and heart rate during RV-LA transit. PAWP was obtained during standard right-heart catheterization. The Spearman correlation coefficient was used to assess the relationship between rPBV and PAWP.

resultsThe study population consisted of 7 individuals who had contrast echocardiography and right-heart catheterization within 3 hours of each other. There was a wide range of right atrial (1-17 mm Hg), mean pulmonary artery (18-42 mm Hg), and PAW pressures (4-26 mm Hg) as well as pulmonary vascular resistance (<1-6 Wood Units). We observed a statistically significant correlation between rPBV and PAWP (r = .85; P = .02).

conclusionRelative PBV derived from contrast echocardiography correlates with PAWP. If validated in larger studies, rPBV could potentially be used as an alternative to invasively determine left-sided filling pressure.

Indexed as

Cardiac CatheterizationAdultBlood VolumeEchocardiographyFemaleHumansMaleMiddle AgedPulmonary ArteryPulmonary Wedge PressureReproducibility of Resultscontrast echocardiographypulmonary arterial wedge pressurepulmonary transit time

Identifiers

PMID29756230
PMCPMC6168381

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.