ArticleChronic stress (Thousand Oaks, Calif.)
Altered Cortical GABA in Female Veterans with Suicidal Behavior: Sex Differences and Clinical Correlates.
Article in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Molecular Mechanisms of Menstrual Cycle-Related Suicide Risk: A Selective Review of Promising Candidate Systems.Biological psychiatry · 2026Review
- Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses.bioRxiv : the preprint server for biology · 2024Article
- Modulators of GABANeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Depressive patient-derived GABA interneurons reveal abnormal neural activity associated with HTR2C.EMBO molecular medicine · 2023Article
- Altered anterior cingulate glutamatergic metabolism in depressed adolescents with current suicidal ideation.Translational psychiatry · 2020Article
- Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies.Molecular psychiatry · 2020Review
- Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions.Frontiers in cellular neuroscience · 2019Review
- The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?Pharmacology & therapeutics · 2018Review
- Glutamine Metabolite Ratios are Related to Thwarted Belongingness and Perceived Burdensomeness: Preliminary Evidence from a Veteran Sample with and Without History of Suicidal Ideation.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Background: Suicide is a public health concern in the civilian and veteran populations. Stressful life events are precipitating factors for suicide. The neurochemical underpinnings of the association between stress/trauma and suicide risk are unclear, especially in regards to sex differences. We hypothesized that gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter may be a neurochemical candidate that is critical in the association between stress and suicide risk in veterans. Methods: Proton magnetic resonance spectroscopy ( Results: We observed no significant differences in GABA/ Creatine+phosphocreatine (Cr+PCr) between veterans with SB (SB+) and without SB (SB-). However, the female SB+ group showed significantly reduced GABA/Cr+PCr vs. the female SB- group. We observed a trend-level significant negative correlation between GABA/Cr+PCr and the defensive avoidance (DA) subscale on the Trauma Symptom Inventory (TSI) in the SB+ group. In contrast, the SB- group exhibited a positive relationship between the two variables. Furthermore, we found significant negative correlations between GABA/Cr+PCr and Hamilton Rating Scale for Depression (HAM-D) scores as well as between GABA/Cr+PCr and several subscales of the TSI in female veterans. Conclusions: This study suggests that reduced GABA/Cr+ PCr ratio in the ACC, which may be related to altered inhibitory capacity, may underlie suicide risk in female veterans. Further, the negative association between GABA/Cr+PCr and stress symptomatology and depression scores suggests that MRS studies may shed light on intermediate phenotypes of SB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.