ArticleSOJ microbiology & infectious diseases2014
Analysis of Gut Microbiome and Diet Modification in Patients with Crohn's Disease.
Article in SOJ microbiology & infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Study Design Complexity and Participant Completion in Dietary Trials for Inflammatory Bowel Disease: A Systematic Review and Metaresearch Study.Advances in nutrition (Bethesda, Md.) · 2026Pooled it
- The Effect of Dietary Interventions on Chronic Inflammatory Diseases in Relation to the Microbiome: A Systematic Review.Nutrients · 2021Pooled it
- Diet and inflammatory bowel disease: The Asian Working Group guidelines.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Guideline
- Noncanonical Surface Glycoconjugates fromJACS Au · 2026Article
- Interactions Between Perioperative Anesthesia Management and Gut Microbiota: Current Research Advances.Cellular and molecular neurobiology · 2026Review
- Unfolding and de-confounding: biologically meaningful causal inference from longitudinal multi-omic networks using METALICA.mSystems · 2024Article
- Mechanisms of Action of Exclusive Enteral Nutrition and Other Nutritional Therapies in Crohn's Disease.Nutrients · 2024Review
- Impact of propionic acid-rich diets on microbial composition of the murine gut microbiome.Frontiers in microbiomes · 2024Article
- Unfolding and De-confounding: Biologically meaningful causal inference from longitudinal multi-omic networks using METALICA.bioRxiv : the preprint server for biology · 2023Article
- Inflammatory Bowel Disease and Customized Nutritional Intervention Focusing on Gut Microbiome Balance.Nutrients · 2022Review
- Crohn's Disease, Host-Microbiota Interactions, and Immunonutrition: Dietary Strategies Targeting Gut Microbiome as Novel Therapeutic Approaches.International journal of molecular sciences · 2022Review
- Article
- Nutritional Management of Thyroiditis of Hashimoto.International journal of molecular sciences · 2022Review
- Inflammatory Bowel Disease and COVID-19: How Microbiomics and Metabolomics Depict Two Sides of the Same Coin.Frontiers in microbiology · 2022Review
- Article
- Diet and microbiome in the beginning of the sequence of gut inflammation.World journal of clinical cases · 2021Review
- Nutritional Therapies and Their Influence on the Intestinal Microbiome in Pediatric Inflammatory Bowel Disease.Nutrients · 2021Review
- The Modification of the Gut Microbiota via Selected Specific Diets in Patients with Crohn's Disease.Nutrients · 2021Review
- Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease.Frontiers in physiology · 2021Review
- Nutrition, IBD and Gut Microbiota: A Review.Nutrients · 2020Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveThe human intestine harbors trillions of commensal microbes that live in homeostasis with the host immune system. Changes in the composition and complexity of gut microbial communities are seen in inflammatory bowel disease (IBD), indicating disruption in host-microbe interactions. Multiple factors including diet and inflammatory conditions alter the microbial complexity. The goal of this study was to develop an optimized methodology for fecal sample processing and to detect changes in the gut microbiota of patients with Crohn's disease receiving specialized diets.
designFecal samples were obtained from patients with Crohn's disease in a pilot diet crossover trial comparing the effects of a specific carbohydrate diet (SCD) versus a low residue diet (LRD) on the composition and complexity of the gut microbiota and resolution of IBD symptoms. The gut microbiota composition was assessed using a high-density DNA microarray PhyloChip.
resultsDNA extraction from fecal samples using a column based method provided consistent results. The complexity of the gut microbiome was lower in IBD patients compared to healthy controls. An increased abundance of
conclusionChanges in the composition and complexity of the gut microbiome were identified in response to specialized carbohydrate diet. The SCD was associated with restructuring of the gut microbial communities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.