ArticleClinical and translational allergy2018
Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007-2012.
Article in Clinical and translational allergy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Blood eosinophil counts in the general population and airways disease: a comprehensive review and meta-analysis.The European respiratory journal · 2022Pooled it
- Serum and nasal lavage fluid eosinophil-derived neurotoxin levels and their determinants in adults.The journal of allergy and clinical immunology. Global · 2025Article
- ARIA Care Pathways 2019: Next-Generation Allergic Rhinitis Care and Allergen Immunotherapy in Malaysia.Journal of personalized medicine · 2023Review
- Distribution of type 2 biomarkers and association with severity, clinical characteristics and comorbidities in the BREATHE real-life asthma population.ERJ open research · 2023Article
- Successful and safe treatment of severe steroid depended eosinophilic asthma with mepolizumab in a woman during pregnancy.Respiratory medicine case reports · 2023Article
- Diseases with oral manifestations among adult asthmatics in Finland: a population-based matched cohort study.BMJ open · 2021Article
- Metabolic Phenotypes in Asthmatic Adults: Relationship with Inflammatory and Clinical Phenotypes and Prognostic Implications.Metabolites · 2021Review
- ARIA 2019 Care Pathways for Allergic Rhinitis in the Kuwait Health Care System.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021Review
- ARIA 2019, Allerjik Rinite Tedavi Yaklaşımı-Türkiye.Turkish thoracic journal · 2020Review
- ARIA guideline 2019: treatment of allergic rhinitis in the German health system.Allergologie select · 2019Article
- Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases.Clinical and translational allergy · 2019Review
- Comparison of hypothesis- and data-driven asthma phenotypes in NHANES 2007-2012: the importance of comprehensive data availability.Clinical and translational allergy · 2019Article
- Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma.Clinical and translational allergy · 2019Review
- How the Smartphone Is Changing Allergy Diagnostics.Current allergy and asthma reports · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association with asthma outcomes.
methodsData from the National Health and Nutrition Examination Surveys (NHANES) 2007-2012 were used (n = 30,442). Adults with current asthma were selected. Asthma phenotypes were: B-Eos-high [if blood eosinophils (B-Eos) ≥ 300/mm
resultsOf the 18,619 adults included, 1059 (5.6% [95% CI 5.1-5.9]) had current asthma. A substantial overlap was observed both in subjects aged < 40 years (44%) and ≥ 40 years (54%). The more prevalent specific overlaps in both age groups were AwObesity associated with either B-Eos-high (15 and 12%, respectively) or B-Eos&FeNO-low asthma (13 and 11%, respectively). About 14% of the current asthma patients were "non-classified". Regardless of phenotype classification, having concomitant phenotypes was significantly associated with (adjusted OR, 95% CI) ≥ 2 controller medications (2.03, 1.16-3.57), and FEV
conclusionsA prevalent overlap of commonly reported asthma phenotypes was observed among asthma patients from the general population, with implications for objective asthma outcomes. A broader approach may be required to better characterize asthma patients and prevent poor asthma outcomes.
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