Evidence map›Paper›PMID 29755660›Full record

ArticleOncotarget2018

Measuring glucocorticoid receptor expression

Charles Truillet, Matthew F L Parker, Loc T Huynh, Junnian Wei, Khaled M Jami, Yung-Hua Wang, Yuqin S Shen, Renuka Sriram, David M Wilson, John Kurhanewicz and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. The Synthesis and Structural Requirements for Measuring Glucocorticoid Receptor Expression In Vivo with (±)-Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Charles TruilletDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Matthew F L ParkerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Loc T HuynhDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Junnian WeiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Khaled M JamiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Yung-Hua WangDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Yuqin S ShenDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Renuka SriramDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
Michael J EvansDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94143, USA.
University of California System · USUniversity of California, San Francisco · US

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Leigh Clarke · 1999 to 2026
$209.7M
TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Development and translation of a novel radioligand to measure pathological changes in glucocorticoid receptor expression in the brainR01MH115043 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EVANS, MICHAEL JOHN · 2018 to 2020
$2.0M
Noninvasive measurement of oncogenic signaling pathways with 89Zr-transferrinR00CA172695 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EVANS, MICHAEL JOHN · 2014 to 2016
$728k
NCI NIH HHS P30 CA082103NCI NIH HHS R00 CA172695NIBIB NIH HHS P41 EB013598NIMH NIH HHS R01 MH115043
6 · The paper itself

Abstract

The glucocorticoid receptor (GR) is an emerging drug target for several common and deadly solid tumors like breast and prostate cancer, and clinical trials studying the antitumor effects of GR antagonists are beginning. Since GR expression can be variable in tumor cells, and virtually all normal mammalian tissues express some GR, we hypothesized that an imaging tool capable of detecting GR positive tumors and/or measuring GR occupancy by drug in tumor and normal tissues could improve the precision application of anti-GR therapies in the clinic. To this end, we developed a fluorine-18 labeled corticosteroid termed GR02 that potently binds the endogenous ligand binding pocket on full length GR. Binding of

Indexed as

cancerglucocorticoid receptorpharmacodynamicspositron emission tomographyprecision medicine

Identifiers

PMID29755660
PMCPMC5945515
OpenAlexW2801093343

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.