Evidence map›Paper›PMID 29755497›Full record

ArticleFrontiers in plant science2018

Lycopene Is Enriched in Tomato Fruit by CRISPR/Cas9-Mediated Multiplex Genome Editing.

Xindi Li, Yanning Wang, Sha Chen, Huiqin Tian, Daqi Fu, Benzhong Zhu, Yunbo Luo, Hongliang Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in plant science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Analysis of the Causes of Split Pit in Peaches.International journal of molecular sciences · 2025
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79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xindi LiCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Yanning WangCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Sha ChenKey Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Huiqin TianCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Daqi FuCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Benzhong ZhuCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Yunbo LuoCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Hongliang ZhuCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous studies have been focusing on breeding tomato plants with enhanced lycopene accumulation, considering its positive effects of fruits on the visual and functional properties. In this study, we used a bidirectional strategy: promoting the biosynthesis of lycopene, while inhibiting the conversion from lycopene to β- and α-carotene. The accumulation of lycopene was promoted by knocking down some genes associated with the carotenoid metabolic pathway. Finally, five genes were selected to be edited in genome by CRISPR/Cas9 system using

Indexed as

carotenoid metabolic pathwayCRISPR/Cas9 systemgenome editinglycopenetomato fruits

Identifiers

PMID29755497
PMCPMC5935052

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.