Evidence map›Paper›PMID 29755469›Full record

ArticleFrontiers in immunology2018

Urinary Peptides As a Novel Source of T Cell Allergen Epitopes.

Ricardo da Silva Antunes, John Pham, Curtis McMurtrey, William H Hildebrand, Elizabeth Phillips, Simon Mallal, John Sidney, Paula Busse, Bjoern Peters, Véronique Schulten and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  3. Cell reports methods · 2022
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  7. Development and Validation of aJournal of immunology research · 2020
    Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Ricardo da Silva AntunesLa Jolla Institute for Allergy and Immunology, La Jolla, CA, United States.
John PhamLa Jolla Institute for Allergy and Immunology, La Jolla, CA, United States.
Curtis McMurtreyDepartment of Microbiology and Immunology, University of Oklahoma, Oklahoma City, OK, United States.
William H HildebrandDepartment of Microbiology and Immunology, University of Oklahoma, Oklahoma City, OK, United States.
Elizabeth PhillipsInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia.
Simon MallalInstitute for Immunology and Infectious Diseases, Murdoch University, Perth, WA, Australia.
John SidneyLa Jolla Institute for Allergy and Immunology, La Jolla, CA, United States.
Paula BusseDivision of Clinical Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Bjoern PetersLa Jolla Institute for Allergy and Immunology, La Jolla, CA, United States.
Véronique SchultenLa Jolla Institute for Allergy and Immunology, La Jolla, CA, United States.
Alessandro SetteLa Jolla Institute for Allergy and Immunology, La Jolla, CA, United States.
La Jolla Institute for Immunology · USUniversity of California, San Diego · USUniversity of Oklahoma · USVanderbilt University · USIcahn School of Medicine at Mount Sinai · US

Funding

Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2015 to 2019
$13.0M
Understanding mechanisms in specific immunotherapy (SIT)U19AI100275 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SETTE, ALESSANDRO · 2012 to 2017
$8.1M
Towards the identification of biomarkers for pediatric milk allergyU19AI135731 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI SETTE, ALESSANDRO · 2018 to 2022
$5.6M
NIAID NIH HHS HHSN272201000052INIAID NIH HHS U19 AI100275NIAID NIH HHS U19 AI135731NIAID NIH HHS UM1 AI114271NIGMS NIH HHS P50 GM115305
6 · The paper itself

Abstract

Mouse allergy in both laboratory workers and in inner-city children is associated with allergic rhinitis and asthma, posing a serious public health concern. Urine is a major source of mouse allergens, as mice spray urine onto their surroundings, where the proteins dry up and become airborne on dust particles. Here, we tested whether oligopeptides that are abundant in mouse urine may contribute to mouse allergic T cell response. Over 1,300 distinct oligopeptides were detected by mass spectrometry analysis of the low molecular weight filtrate fraction of mouse urine (LoMo). Posttranslationally modified peptides were common, accounting for almost half of total peptides. A pool consisting of 225 unique oligopeptides of 13 residues or more in size identified within was tested for its capacity to elicit T cell reactivity in mouse allergic donors. Following 14-day

Indexed as

AdultAllergensAnimalsAsthmaEpitopes, T-LymphocyteFemaleHumansImmunoglobulin EMaleMiceMiddle AgedPeptidesProteomeProteomicsRhinitis, AllergicT-LymphocytesAllergensEpitopes, T-LymphocyteImmunoglobulin EPeptidesProteomeallergenepitopesmousepeptidesT cellurine

Identifiers

PMID29755469
PMCPMC5932195
OpenAlexW2800303305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.