Evidence map›Paper›PMID 29755449›Full record

ArticleFrontiers in immunology2018

Immunization Elicits Antigen-Specific Antibody Sequestration in Dorsal Root Ganglia Sensory Neurons.

Manojkumar Gunasekaran, Prodyot K Chatterjee, Andrew Shih, Gavin H Imperato, Meghan Addorisio, Gopal Kumar, Annette Lee, John F Graf, Dan Meyer, Michael Marino and 12 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026
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  10. Is fibromyalgia an autoimmune illness?Clinical rheumatology · 2021
    Article
  11. Review
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 3 countries.

Manojkumar GunasekaranCenter for Biomedical Science, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Prodyot K ChatterjeeCenter for Biomedical Science, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Andrew ShihCenter for Genomics and Human Genetics, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Gavin H ImperatoCenter for Biomedical Science, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Meghan AddorisioCenter for Biomedical Science, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Gopal KumarCenter for Biomedical Science, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Annette LeeCenter for Genomics and Human Genetics, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
John F GrafGE Global Research Center, Niskayuna, NY, United States.
Dan MeyerGE Global Research Center, Niskayuna, NY, United States.
Michael MarinoGE Global Research Center, Niskayuna, NY, United States.
Christopher PuleoGE Global Research Center, Niskayuna, NY, United States.
Jeffrey AsheGE Global Research Center, Niskayuna, NY, United States.
Maureen A CoxThe Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada.
Tak W MakThe Campbell Family Institute for Breast Cancer Research, University Health Network, Toronto, ON, Canada.
Chad BoutonCenter for Bioelectronic Medicine, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Barbara SherryElmezzi Graduate School, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Betty DiamondElmezzi Graduate School, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Ulf AnderssonDepartment of Women's and Children's Health, Karolinska Institutet, Solna, Sweden.
Thomas R ColemanCenter for Molecular Innovation, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Christine N MetzCenter for Biomedical Science, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Kevin J TraceyCenter for Biomedical Science, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Sangeeta S ChavanCenter for Biomedical Science, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, United States.
Feinstein Institute for Medical Research · USGE Global Research (United States) · USNorthwell Health · USDonald & Barbara Zucker School of Medicine at Hofstra/Northwell · USUniversity Health Network · CAKarolinska Institutet · SE

Funding

Targeting cognitive and immune impairment in sepsis survivorsP01AI102852 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI VOLPE, BRUCE THOMAS · 2014 to 2018
$11.5M
Molecular Basis of Bioelectronic MedicineR35GM118182 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI TRACEY, KEVIN J · 2016 to 2025
$7.3M
NIAID NIH HHS P01 AI102852NIGMS NIH HHS R35 GM118182
6 · The paper itself

Abstract

The immune and nervous systems are two major organ systems responsible for host defense and memory. Both systems achieve memory and learning that can be retained, retrieved, and utilized for decades. Here, we report the surprising discovery that peripheral sensory neurons of the dorsal root ganglia (DRGs) of immunized mice contain antigen-specific antibodies. Using a combination of rigorous molecular genetic analyses, transgenic mice, and adoptive transfer experiments, we demonstrate that DRGs do not synthesize these antigen-specific antibodies, but rather sequester primarily IgG

Indexed as

AnimalsAntibodiesAntigensB-LymphocytesCells, CulturedGanglia, SpinalImmunity, HumoralImmunizationInflammationMaleMiceMice, Inbred C57BLMice, TransgenicNeuroimmunomodulationSensory Receptor CellsAntibodiesAntigensantibodiesDRGinflammationneural circuitssensory neurons

Identifiers

PMID29755449
PMCPMC5932385
OpenAlexW2802321333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.