ArticleFrontiers in neurology2018
Impulsivity in Parkinson's Disease Is Associated With Alterations in Affective and Sensorimotor Striatal Networks.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Impulse Control Disorders Are Independent of Parkinson Disease Motor Subtypes.medRxiv : the preprint server for health sciences · 2026Article
- Impulsivity in cerebellar ataxia: an online, multidimensional assessment.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Aberrant striatal firing mediates impulsive decision-making in a mouse model of Parkinson's disease.Brain : a journal of neurology · 2026Article
- Neuropsychological aspects of impulse control disorders in Parkinson's disease.Frontiers in aging neuroscience · 2026Review
- Impulse control disorders in Parkinson's disease: What's new?Journal of neurology · 2025Review
- Resting-State Functional MRI Approaches to Parkinsonisms and Related Dementia.Current neurology and neuroscience reports · 2024Review
- Cognition and movement in neurodegenerative disorders: a dynamic duo.Neural regeneration research · 2024Article
- Impulsivity Traits in Parkinson's Disease: A Systematic Review and Meta-Analysis.Movement disorders clinical practice · 2023Review
- Neural correlates of risky decision making in Parkinson's disease patients with impulse control disorders.Experimental brain research · 2022Article
- A single-arm open-label pilot study of brief mindfulness meditation to control impulsivity in Parkinson's disease.PloS one · 2022Article
- Is there a Neurobiological Rationale for the Utility of the Iowa Gambling Task in Parkinson's Disease?Journal of Parkinson's disease · 2021Review
- Neural Encoding of the Reliability of Directional Information During the Preparation of Targeted Movements.Frontiers in neuroscience · 2021Article
- Impulse Control Disorders in Parkinson's Disease: From Bench to Bedside.Frontiers in neuroscience · 2021Review
- Unmasking neurobiological commonalities between addictive disorders and impulse control disorders in Parkinson's disease.Brain imaging and behavior · 2020Review
- Increased large-scale inter-network connectivity in relation to impulsivity in Parkinson's disease.Scientific reports · 2020Article
- Increased large-scale inter-network connectivity in relation to impulsivity in Parkinson's disease.Scientific reports · 2020Article
- Self-reported rates of impulsivity in Parkinson's Disease.Annals of clinical and translational neurology · 2020Article
- Reduced volumes of the external and internal globus pallidus in male heroin addicts: a postmortem study.European archives of psychiatry and clinical neuroscience · 2019Article
- Impulse Control Disorders in Parkinson's Disease. A Brief and Comprehensive Review.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
A subset of patients with Parkinson's disease (PD) experiences problems with impulse control, characterized by a loss of voluntary control over impulses, drives, or temptations regarding excessive hedonic behavior. The present study aimed to better understand the neural basis of such impulse control disorders (ICDs) in PD. We collected resting-state functional connectivity and structural MRI data from 21 PD patients with ICDs and 30 patients without such disorders. To assess impulsivity, all patients completed the Barratt Impulsiveness Scale and performed an information-gathering task. MRI results demonstrated substantial differences in neural characteristics between PD patients with and without ICDs. Results showed that impulsivity was linked to alterations in affective basal ganglia circuitries. Specifically, reduced frontal-striatal connectivity and GPe volume were associated with more impulsivity. We suggest that these changes affect decision making and result in a preference for risky or inappropriate actions. Results further showed that impulsivity was linked to alterations in sensorimotor striatal networks. Enhanced connectivity within this network and larger putamen volume were associated with more impulsivity. We propose that these changes affect sensorimotor processing such that patients have a greater propensity to act. Our findings suggest that the two mechanisms jointly contribute to impulsive behaviors in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.