Evidence map›Paper›PMID 29755380›Full record

ReviewFrontiers in psychology2018

Effects of Physical Exercise on Cognitive Functioning and Wellbeing: Biological and Psychological Benefits.

Laura Mandolesi, Arianna Polverino, Simone Montuori, Francesca Foti, Giampaolo Ferraioli, Pierpaolo Sorrentino, Giuseppe Sorrentino

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in psychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06775548 (Effects of Exercises and Vitamins on Oxidative Stress & Inflammatory Markers Among Patients with Depression), which is not on this map. Cited by 462 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
462citing papers in PubMed, 10 pooled it
38.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06775548 naenrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Effects of Exercises and Vitamins on Oxidative Stress & Inflammatory Markers Among Patients with Depression

TypeinterventionalSponsorZiauddin UniversityRan2024 to 2025Enrolled116ConditionsDepression DisordersArmsAerobic Exercises + Vitamin E, Resistance Exercises + Vitamin E, Aerobic Exercises + Vitamin D, Resistance Exercises + Vitamin D
3 · Its place in the literature

Who cites it

462 citing papers in PubMed, 10 syntheses or guidelines pooled it, 981 citations in OpenAlex.

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402 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Laura MandolesiDepartment of Movement Sciences and Wellbeing, Parthenope University of Naples, Naples, Italy.
Arianna PolverinoDepartment of Movement Sciences and Wellbeing, Parthenope University of Naples, Naples, Italy.
Simone MontuoriDepartment of Movement Sciences and Wellbeing, Parthenope University of Naples, Naples, Italy.
Francesca FotiIRCCS Fondazione Santa Lucia, Rome, Italy.
Giampaolo FerraioliDepartment of Science and Technology, Parthenope University of Naples, Naples, Italy.
Pierpaolo SorrentinoDepartment of Engineering, Parthenope University of Naples, Naples, Italy.
Giuseppe SorrentinoDepartment of Movement Sciences and Wellbeing, Parthenope University of Naples, Naples, Italy.
Parthenope University of Naples · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Much evidence shows that physical exercise (PE) is a strong gene modulator that induces structural and functional changes in the brain, determining enormous benefit on both cognitive functioning and wellbeing. PE is also a protective factor for neurodegeneration. However, it is unclear if such protection is granted through modifications to the biological mechanisms underlying neurodegeneration or through better compensation against attacks. This concise review addresses the biological and psychological positive effects of PE describing the results obtained on brain plasticity and epigenetic mechanisms in animal and human studies, in order to clarify how to maximize the positive effects of PE while avoiding negative consequences, as in the case of exercise addiction.

Indexed as

braincognitionepigenetic mechanismsphysical exercisewellbeing

Identifiers

PMID29755380
PMCPMC5934999
OpenAlexW2799336310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.