ReviewFrontiers in pharmacology2018
Endophytic Fungi-Alternative Sources of Cytotoxic Compounds: A Review.
Review in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
94 citing papers in PubMed.
- Effective bio-activities of the metal nanoparticles mycosynthesized by the plants' fungal endophytes.Microbial cell factories · 2026Review
- From mycelium to medicine: fungal strategies in the fight against resistance, cancer, and viral infections-insights from egyptian studies.Folia microbiologica · 2026Review
- Characterization of an Endophytic Fusarium odoratissimum Strain 25Current microbiology · 2026Article
- Bee derived Aspergillus oryzae as a novel reservoir for selective anticancer metabolites with integrated bioprocess optimization and multi cell line evaluation.BMC microbiology · 2026Article
- Comparative Metabolomic Profiling of Resistant and SusceptiblePlants (Basel, Switzerland) · 2026Article
- Plant Endophytes and their Secondary Metabolites: A Source of Bioactive Compounds.Current drug research reviews · 2026Review
- Secondary metabolites of Minutisphaera thailandensis and Hongkongmyces kokensis revealed by LC-QTOF-MS and their antimicrobial and cytotoxic activities.Scientific reports · 2025Article
- Exploring the modern approaches to enhance fungal endophyte-derived bioactive secondary metabolites.3 Biotech · 2025Review
- Endophytes of Zingiberaceae: distribution and bioactivity of their bioactive metabolites.Archives of microbiology · 2025Review
- Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights.Microbial cell factories · 2025Article
- Exploring the Antimicrobial, Antioxidant and Extracellular Enzymatic Activities of Culturable Endophytic Fungi Isolated from the Leaves ofMicroorganisms · 2025Article
- Emestrin-type epipolythiodioxopiperazines from Aspergillus nidulans with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways.Natural products and bioprospecting · 2025Article
- Antimicrobial and antiproliferative activity of biosynthesized manganese nanocomposite with amide derivative originated by endophytic Aspergillus terreus.Microbial cell factories · 2025Article
- Antimicrobial and Cytotoxic Potential of Endophytic Aspergillus versicolor Isolate from the Medicinal Plant Plectranthus amboinicus.Current microbiology · 2025Article
- Antibacterial potential and chromatographic profiling of bioactive compounds from endophyticPeerJ · 2025Article
- Antimicrobial and cytotoxic activities of natural (Z)-13-docosenamide derived fromFrontiers in cellular and infection microbiology · 2025Article
- Endophytic fungi: A future prospect for breast cancer therapeutics and drug development.Heliyon · 2024Review
- Biotechnological approaches for the production of camptothecin.Applied microbiology and biotechnology · 2024Review
- Marine seaweed endophytic fungi-derived active metabolites promote reactive oxygen species-induced cell cycle arrest and apoptosis in human breast cancer cells.Molecular biology reports · 2024Article
- Molecular authentication, metabolite profiling and in silico-in vitro cytotoxicity screening of endophytic3 Biotech · 2024Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is a major cause of death worldwide, with an increasing number of cases being reported annually. The elevated rate of mortality necessitates a global challenge to explore newer sources of anticancer drugs. Recent advancements in cancer treatment involve the discovery and development of new and improved chemotherapeutics derived from natural or synthetic sources. Natural sources offer the potential of finding new structural classes with unique bioactivities for cancer therapy. Endophytic fungi represent a rich source of bioactive metabolites that can be manipulated to produce desirable novel analogs for chemotherapy. This review offers a current and integrative account of clinically used anticancer drugs such as taxol, podophyllotoxin, camptothecin, and vinca alkaloids in terms of their mechanism of action, isolation from endophytic fungi and their characterization, yield obtained, and fungal strain improvement strategies. It also covers recent literature on endophytic fungal metabolites from terrestrial, mangrove, and marine sources as potential anticancer agents and emphasizes the findings for cytotoxic bioactive compounds tested against specific cancer cell lines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.