Evidence map›Paper›PMID 29755326›Full record

ArticleFrontiers in neuroanatomy2018

Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study.

Federico S Lucia, Jesús Pacheco-Torres, Susana González-Granero, Santiago Canals, María-Jesús Obregón, José M García-Verdugo, Pere Berbel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroanatomy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Mapping Thyroid Hormone Action in the Human Brain.Thyroid : official journal of the American Thyroid Association · 2024
    Review
  3. Article
  4. Effect of the Fetal THRB Genotype on the Placenta.The Journal of clinical endocrinology and metabolism · 2023
    Article
  5. Article
  6. Nutrition and Brain Development.Current topics in behavioral neurosciences · 2022
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Federico S LuciaDepartamento de Histología y Anatomía, Facultad de Medicina, Universidad Miguel Hernández, Sant Joan d'Alacant, Alicante, Spain.
Jesús Pacheco-TorresInstituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, Alicante, Spain.
Susana González-GraneroLaboratorio de Neurobiología Comparada, Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Universitat de València, Valencia, Spain.
Santiago CanalsInstituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, Alicante, Spain.
María-Jesús ObregónInstituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Madrid, Spain.
José M García-VerdugoLaboratorio de Neurobiología Comparada, Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Universitat de València, Valencia, Spain.
Pere BerbelDepartamento de Histología y Anatomía, Facultad de Medicina, Universidad Miguel Hernández, Sant Joan d'Alacant, Alicante, Spain.
Centro de Investigación Biomédica en Red · ESUniversitat de Miguel Hernández d'Elx · ESConsejo Superior de Investigaciones Científicas · ESInstituto de Neurociencias · ESUniversidad Autónoma de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid hormone deficiency at early postnatal ages affects the cytoarchitecture and function of neocortical and telencephalic limbic areas, leading to impaired associative memory and in a wide spectrum of neurological and mental diseases. Neocortical areas project interhemispheric axons mostly through the corpus callosum and to a lesser extent through the anterior commissure (AC), while limbic areas mostly project through the AC and hippocampal commissures. Functional magnetic resonance data from children with late diagnosed congenital hypothyroidism and abnormal verbal memory processing, suggest altered ipsilateral and contralateral telencephalic connections. Gestational hypothyroidism affects AC development but the possible effect of transient and chronic postnatal hypothyroidism, as occurs in late diagnosed neonates with congenital hypothyroidism and in children growing up in iodine deficient areas, still remains unknown. We studied AC development using

Indexed as

bipolar disorderscongenital hypothyroidismiodine dietlimbic systempsychiatric diseasesrodent behaviorschizophreniathyroid hormones

Identifiers

PMID29755326
PMCPMC5935182
OpenAlexW2802383209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.