Evidence map›Paper›PMID 29755299›Full record

ArticleContrast media & molecular imaging2018

Nobuyoshi Fukumitsu, Skye Hsin-Hsien Yeh, Leo Garcia Flores Ii, Uday Mukhopadhyay, Daniel Young, Kazuma Ogawa, Hwan-Jeong Jeong, William Tong, Juri G Gelovani

Open access · hybridAbstract read
In one paragraph

Article in Contrast media & molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Molecular imaging · 2021
    Article
  4. Review
  5. ACS medicinal chemistry letters · 2019
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Nobuyoshi FukumitsuProton Medical Research Center, University of Tsukuba, Tsukuba, Japan.ORCID 0000-0003-2417-8199
Skye Hsin-Hsien YehBrain Research Center, National Yang-Ming University, Taipei, Taiwan.ORCID 0000-0002-7495-1146
Leo Garcia Flores IiPediatrics Research, UT MD Anderson Cancer Center, Houston, TX, USA.
Uday MukhopadhyayCyclotron Research Facility, Center for Advanced Biomedical Imaging, UT MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-3442-3955
Daniel YoungCyclotron Research Facility, Center for Advanced Biomedical Imaging, UT MD Anderson Cancer Center, Houston, TX, USA.
Kazuma OgawaInstitute for Frontier Science Initiative, Kanazawa University, Kanazawa, Japan.ORCID 0000-0002-1691-7302
Hwan-Jeong JeongDepartment of Nuclear Medicine, Chonbuk National University Medical School & Hospital, Jeonju, Republic of Korea.
William TongCyclotron Research Facility, Center for Advanced Biomedical Imaging, UT MD Anderson Cancer Center, Houston, TX, USA.
Juri G GelovaniOncology, Neurosurgery, OBGYN, and Biomedical Engineering, Wayne State University, Detroit, MI, USA.ORCID 0000-0002-8413-6161
Jeonbuk National University · KRKanazawa University · JPNational Yang Ming Chiao Tung University · TWThe University of Texas MD Anderson Cancer Center · USUniversity of Tsukuba · JPWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Histone deacetylases (HDACs) regulate gene expression by changing histone deacetylation status. Neurotoxicity is one of the major side effects of cisplatin, which reacts with deoxyribonucleic acid (DNA) and has excellent antitumor effects. Suberoylanilide hydroxamic acid (SAHA) is an HDAC inhibitor with neuroprotective effects against cisplatin-induced neurotoxicity. Purpose: We investigated how cisplatin with and without SAHA pretreatment affects HDAC expression/activity in the brain by using 6-([ Materials and Methods: [ Results: The Conclusions: [

Indexed as

AnimalsAntineoplastic AgentsBrainCisplatinFluorine RadioisotopesFluorodeoxyglucose F18Histone DeacetylasesMiceNeurotoxicity SyndromesPositron-Emission TomographyRadiopharmaceuticalsVorinostatAntineoplastic AgentsCisplatinFluorine-18Fluorine RadioisotopesFluorodeoxyglucose F18Histone DeacetylasesRadiopharmaceuticalsVorinostat

Identifiers

PMID29755299
PMCPMC5884410
OpenAlexW2793811432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.