Evidence map›Paper›PMID 29755006›Full record

ReviewEuropean urology2018

Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System).

Valeria Panebianco, Yoshifumi Narumi, Ersan Altun, Bernard H Bochner, Jason A Efstathiou, Shaista Hafeez, Robert Huddart, Steve Kennish, Seth Lerner, Rodolfo Montironi and 8 more

4 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in European urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 310 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
310citing papers in PubMed, 5 pooled it
43.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04588168 naunknown statusnot on this map

Multi-parameter Magnetic Resonance Imaging for Early Evaluation of the Efficacy of Neoadjuvant Chemotherapy With Modified GC Regimen for Urothelial Carcinoma

TypeinterventionalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2018 to 2026Enrolled100ConditionsBladder CancerArmsChemotherapy, Immediate Multiparametric MRI, Cystectomy and Lymphadenectomy, conventional Multiparametric MRI, Baseline Multiparametric MRI
NCT05096533 unknown statusnot on this mapstarted 2021, after this paper: background citation

Prospective Multi-center Clinical Study on the Application Value of Artificial Intelligence in MRI Precision Diagnosis and Treatment of Bladder Cancer

TypeobservationalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2021 to 2023Enrolled150ConditionsBladder Cancer
NCT05097404 unknown statusnot on this mapstarted 2021, after this paper: background citation

Clinical Utility of Vesical Imaging Report and Data System (VI-RADS) in Diagnosis of Muscle Invasive Bladder Cancer

TypeobservationalSponsorSamsung Medical CenterRan2021 to 2024Enrolled73ConditionsRadical Cystectomy, Muscle-Invasive Bladder Carcinoma, Multiparametric MRI, Vesical Imaging Report and Data System
NCT05783271 narecruitingnot on this mapstarted 2025, after this paper: background citation

Validity of Parametric MRI Using VIRAD Scoring in the Diagnosis of Cancer Bladder

TypeinterventionalSponsorAssiut UniversityRan2025 to 2026Enrolled58ConditionsBladder CancerArmsGadolinium
3 · Its place in the literature

Who cites it

310 citing papers in PubMed, 5 syntheses or guidelines pooled it, 613 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Phase II Trial of Risk-Enabled Therapy After Neoadjuvant Chemotherapy for Muscle-Invasive Bladder Cancer (RETAIN 1).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Trial
  8. Trial
  9. Image directed redesign of bladder cancer treatment pathways: the BladderPath RCT.Health technology assessment (Winchester, England) · 2024
    Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. The Stalk Sign in Bladder Cancer: CEUS Versus MRI.Diagnostics (Basel, Switzerland) · 2026
    Article

250 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 15 institutions in 7 countries.

Valeria PanebiancoDepartment of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Italy. Electronic address: valeria.panebianco@uniroma1.it.
Yoshifumi NarumiDepartment of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan.
Ersan AltunDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Bernard H BochnerDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Jason A EfstathiouDepartment of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Shaista HafeezThe Institute of Cancer Research, Sutton, Surrey, UK; The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK.
Robert HuddartThe Institute of Cancer Research, Sutton, Surrey, UK; The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK.
Steve KennishDepartment of Radiology, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.
Seth LernerScott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
Rodolfo MontironiSection of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy.
Valdair F MugliaImaging Division, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Brazil.
Georg SalomonMartini Clinic, University Clinic Hamburg Eppendorf, Hamburg, Germany.
Stephen ThomasDepartment of Radiology, University of Chicago, Chicago, IL, USA.
Hebert Alberto VargasDepartment of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
J Alfred WitjesDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Mitsuru TakeuchiDepartment of Radiology, Radiolonet Tokai, Nagoya, Japan.
Jelle BarentszDepartment of Radiology, Radboud University Medical Center, Nijmegen, The Netherlands.
James W F CattoAcademic Urology Unit, University of Sheffield, Sheffield, UK.
Institute of Cancer Research · GBMemorial Sloan Kettering Cancer Center · USBaylor College of Medicine · USHarvard University · USMarche Polytechnic University · ITOsaka Medical and Pharmaceutical University · JPRadboud University Medical Center · NLRadboud University Nijmegen · NLSapienza University of Rome · ITSheffield Teaching Hospitals NHS Foundation Trust · GBUniversidade de São Paulo · BRUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Chicago · USUniversity of North Carolina at Chapel Hill · USUniversity of Sheffield · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Cancer Research UK 10588Cancer Research UK 19727NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

contextManagement of bladder cancer (BC) is primarily driven by stage, grade, and biological potential. Knowledge of each is derived using clinical, histopathological, and radiological investigations. This multimodal approach reduces the risk of error from one particular test, but may present a staging dilemma when results conflict. Multiparametric magnetic resonance imaging (mpMRI) may improve patient care through imaging of the bladder with better resolution of the tissue planes than computed tomography and without radiation exposure.

objectiveTo define a standardized approach to imaging and reporting mpMRI for BC, by developing a VI-RADS score. EVIDENCE ACQUISITION: We created VI-RADS (Vesical Imaging-Reporting And Data System) through consensus using existing literature. EVIDENCE SYNTHESIS: We describe standard imaging protocols and reporting criteria (including size, location, multiplicity, and morphology) for bladder mpMRI. We propose a five-point VI-RADS score, derived using T2-weighted MRI, diffusion-weighted imaging, and dynamic contrast enhancement, which suggests the risks of muscle invasion. We include sample images used to understand VI-RADS.

conclusionsWe hope that VI-RADS will standardize reporting, facilitate comparisons between patients, and in future years, will be tested and refined if necessary. While we do not advocate mpMRI for all patients with BC, this imaging may compliment pathology or reduce radiation-based imaging. Bladder mpMRI may be most useful in patients with non-muscle-invasive cancers, in expediting radical treatment or for determining response to bladder-sparing approaches. PATIENT SUMMARY: Magnetic resonance imaging (MRI) scans for bladder cancer are becoming more common and may provide accurate information that helps improve patient care. Here, we describe a standardized reporting criterion for bladder MRI. This should improve communication between doctors and allow better comparisons between patients.

Indexed as

Data SystemsConsensusContrast MediaDiffusion Magnetic Resonance ImagingHumansImage Interpretation, Computer-AssistedNeoplasm StagingObserver VariationPredictive Value of TestsReproducibility of ResultsUrinary Bladder NeoplasmsContrast MediaBladder cancerMultiparametric magnetic resonance imagingRADSScoringStaging

Identifiers

PMID29755006
PMCPMC6690492
OpenAlexW2800613296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.