ArticleCurrent biology : CB2018
Replay of Episodic Memories in the Rat.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 99 citations in OpenAlex.
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- Rats replay episodic memories in context.Current biology : CB · 2026Article
- Disruption of theta-timescale spiking impairs learning but spares hippocampal replay.bioRxiv : the preprint server for biology · 2025Article
- Dimensions of corvid consciousness.Animal cognition · 2025Review
- Transient DREADD Manipulation of the Dorsal Dentate Gyrus in Rats Impairs Initial Learning of Place-Outcome Associations.Hippocampus · 2025Article
- Validation of a rodent model of episodic memory replay.Learning & behavior · 2025Article
- Why might animals remember? A functional framework for episodic memory research in comparative psychology.Learning & behavior · 2025Review
- Mental time travel in the rat.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Is episodic-like memoryPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Transitional gradation and the distinction between episodic and semantic memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Neural waves and computation in a neural net model II: Data-like structures and the dynamics of episodic memory.Journal of computational neuroscience · 2024Article
- Review
- Impaired episodic-like memory in a mouse model of Alzheimer's disease is associated with hyperactivity in prefrontal-hippocampal regions.Disease models & mechanisms · 2023Article
- Challenges and advanced concepts for the assessment of learning and memory function in mice.Frontiers in behavioral neuroscience · 2023Review
- Memory and eating: A bidirectional relationship implicated in obesity.Neuroscience and biobehavioral reviews · 2022Review
- Pigeons acquire the 1-back task: Implications for implicit versus explicit learning?Learning & behavior · 2021Article
- Postmeal optogenetic inhibition of dorsal hippocampal principal neurons increases future intake in a time-dependent manner.Neurobiology of learning and memory · 2021Article
- Episodic-like memory is preserved with age in cuttlefish.Proceedings. Biological sciences · 2021Article
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16 authors at 1 institution in 1 country.
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Abstract
Vivid episodic memories in people have been characterized as the replay of multiple unique events in sequential order [1-3]. The hippocampus plays a critical role in episodic memories in both people and rodents [2, 4-6]. Although rats remember multiple unique episodes [7, 8], it is currently unknown if animals "replay" episodic memories. Therefore, we developed an animal model of episodic memory replay. Here, we show that rats can remember a trial-unique stream of multiple episodes and the order in which these events occurred by engaging hippocampal-dependent episodic memory replay. We document that rats rely on episodic memory replay to remember the order of events rather than relying on non-episodic memories. Replay of episodic memories survives a long retention-interval challenge and interference from the memory of other events, which documents that replay is part of long-term episodic memory. The chemogenetic activating drug clozapine N-oxide (CNO), but not vehicle, reversibly impairs episodic memory replay in rats previously injected bilaterally in the hippocampus with a recombinant viral vector containing an inhibitory designer receptor exclusively activated by a designer drug (DREADD; AAV8-hSyn-hM4Di-mCherry). By contrast, two non-episodic memory assessments are unaffected by CNO, showing selectivity of this hippocampal-dependent impairment. Our approach provides an animal model of episodic memory replay, a process by which the rat searches its representations in episodic memory in sequential order to find information. Our findings using rats suggest that the ability to replay a stream of episodic memories is quite old in the evolutionary timescale.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.