Evidence map›Paper›PMID 29754837›Full record

Trial reportParkinsonism & related disorders2018

Effects of exercise on gait and motor imagery in people with Parkinson disease and freezing of gait.

Peter S Myers, Marie E McNeely, Kristen A Pickett, Ryan P Duncan, Gammon M Earhart

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Parkinsonism & related disorders, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Functional MRI in Parkinson's disease with freezing of gait: a systematic review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  3. Pooled it
  4. Trial
  5. A Randomized, Controlled Trial of Exercise for Parkinsonian Individuals With Freezing of Gait.Movement disorders : official journal of the Movement Disorder Society · 2020
    Trial
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  20. [Research advancements of motor imagery for motor function recovery after stroke].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Peter S MyersProgram in Physical Therapy, Washington University in St. Louis School of Medicine, Campus Box 8502, 4444 Forest Park Blvd, Suite 11101, St. Louis, MO 63108, USA. Electronic address: petersmyers@wustl.edu.
Marie E McNeelyProgram in Physical Therapy, Washington University in St. Louis School of Medicine, Campus Box 8502, 4444 Forest Park Blvd, Suite 11101, St. Louis, MO 63108, USA; Department of Neurology, Washington University in St. Louis School of Medicine, Campus Box 8111, 660 S. Euclid, St. Louis, MO 63110, USA. Electronic address: mcneelym@wustl.edu.
Kristen A PickettOccupational Therapy Program, Department of Kinesiology, University of Wisconsin- Madison School of Education, Unit II Gym, 2000 Observatory Drive, Madison, WI 53706, USA. Electronic address: kristen.pickett@wisc.edu.
Ryan P DuncanProgram in Physical Therapy, Washington University in St. Louis School of Medicine, Campus Box 8502, 4444 Forest Park Blvd, Suite 11101, St. Louis, MO 63108, USA; Department of Neurology, Washington University in St. Louis School of Medicine, Campus Box 8111, 660 S. Euclid, St. Louis, MO 63110, USA. Electronic address: duncanr@wustl.edu.
Gammon M EarhartProgram in Physical Therapy, Washington University in St. Louis School of Medicine, Campus Box 8502, 4444 Forest Park Blvd, Suite 11101, St. Louis, MO 63108, USA; Department of Neurology, Washington University in St. Louis School of Medicine, Campus Box 8111, 660 S. Euclid, St. Louis, MO 63110, USA; Department of Neuroscience, Washington University in St. Louis School of Medicine, Campus Box 8108, 660 S. Euclid, St. Louis, MO 63110, USA. Electronic address: earhartg@wustl.edu.
Washington University in St. Louis · USUniversity of Wisconsin–Madison · US

Funding

MULTICENTER CAREER DEVELOPMENT PROGRAM FOR PHYSICAL AND OCCUPATIONAL THERAPYK12HD055931 · NICHD · WASHINGTON UNIVERSITY · PI HAYES, MARCIE HARRIS · 2007 to 2021
$12.7M
DOCTORAL TRAINING PROGRAM IN MOVEMENT SCIENCET32HD007434 · NICHD · WASHINGTON UNIVERSITY · PI Michael D Harris, Catherine Lang · 1993 to 2026
$4.2M
EXERCISE AND PARKINSON'S: COMPARING INTERVENTIONS AND EXPLORING NEURAL MECHANISMSR01NS077959 · NINDS · WASHINGTON UNIVERSITY · PI EARHART, GAMMON M. · 2012 to 2016
$1.9M
NICHD NIH HHS K12 HD055931NICHD NIH HHS T32 HD007434NINDS NIH HHS R01 NS077959
6 · The paper itself

Abstract

introductionExercise improves gait in Parkinson disease (PD), but whether exercise differentially affects people with PD with (freezers) and without freezing of gait (non-freezers) remains unclear. This study examines exercise's effects on gait performance, neural correlates related to these effects, and potential neural activation differences between freezers and non-freezers during motor imagery (MI) of gait.

methodsThirty-seven participants from a larger exercise intervention completed behavioral assessments and functional magnetic resonance imaging (fMRI) scans before and after a 12-week exercise intervention. Gait performance was characterized using gait velocity and stride length, and a region of interest (ROI) fMRI analysis examined task-based blood oxygen-level dependent (BOLD) signal changes of the somatomotor network (SMN) during MI of forward (IMG-FWD) and backward (IMG-BWD) gait.

resultsVelocity (F(1,34) = 55.04, p < 0.001) and stride length (F(1,34) = 77.58, p < 0.001) were significantly lower for backward versus forward walking in all participants. The ROI analysis showed freezers had lower BOLD signal compared to non-freezers in the cerebellum (F(1,32) = 7.01, p = 0.01), primary motor (left: F(1,32) = 7.09, p = 0.01; right: F(1,32) = 7.45, p = 0.01), and primary sensory (left: F(1,32) = 9.59, p = 0.004; right: F(1,32) = 8.18, p = 0.007) cortices during IMG-BWD only. The evidence suggests the exercise intervention did not affect gait or BOLD signal during MI.

conclusionWhile all participants had significantly slower and shorter backward velocity and stride length, respectively, the exercise intervention had no effect. Similarly, BOLD signal during MI did not change with exercise; however, freezers had significantly lower BOLD signal during IMG-BWD compared to non-freezers. This suggests potential decreased recruitment of the SMN during MI of gait in freezers.

Indexed as

Outcome Assessment, Health CareAgedCerebellumExercise TherapyFemaleGait Disorders, NeurologicHumansImaginationMagnetic Resonance ImagingMaleMiddle AgedMotor ActivityNerve NetParkinson DiseaseSensorimotor CortexCerebellumFreezing of gaitNeuroimagingParkinson disease

Identifiers

PMID29754837
PMCPMC6120800
OpenAlexW2801618339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.