Evidence map›Paper›PMID 29754714›Full record

ArticleBiophysical journal2018

Membrane Potential Distinctly Modulates Mobility and Signaling of IL-2 and IL-15 Receptors in T Cells.

Éva Nagy, Gábor Mocsár, Veronika Sebestyén, Julianna Volkó, Ferenc Papp, Katalin Tóth, Sándor Damjanovich, György Panyi, Thomas A Waldmann, Andrea Bodnár and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. IL-15Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
  6. Article
  7. Article
  8. KCells · 2020
    Review
  9. Review
  10. IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti-IL-2Rα therapies.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Éva NagyDepartment of Biophysics and Cell Biology, Faculty of Medicine.
Gábor MocsárDepartment of Biophysics and Cell Biology, Faculty of Medicine.
Veronika SebestyénDepartment of Biophysics and Cell Biology, Faculty of Medicine.
Julianna VolkóDepartment of Biophysics and Cell Biology, Faculty of Medicine.
Ferenc PappDepartment of Biophysics and Cell Biology, Faculty of Medicine; MTA-DE- NAP B Ion Channel Structure-Function Research Group, RCMM, University of Debrecen, Debrecen, Hungary.
Katalin TóthDivision Biophysics of Macromolecules, German Cancer Research Center, Heidelberg, Germany.
Sándor DamjanovichDepartment of Biophysics and Cell Biology, Faculty of Medicine.
György PanyiDepartment of Biophysics and Cell Biology, Faculty of Medicine; MTA-DE- NAP B Ion Channel Structure-Function Research Group, RCMM, University of Debrecen, Debrecen, Hungary.
Thomas A WaldmannLymphoid Malignancies Branch, National Institutes of Health, Bethesda, Maryland.
Andrea BodnárDepartment of Biophysics and Cell Biology, Faculty of Medicine.
György VámosiDepartment of Biophysics and Cell Biology, Faculty of Medicine. Electronic address: vamosig@med.unideb.hu.
University of Debrecen · HUGerman Cancer Research Center · DEInstitute of Cell Biophysics · RUNational Institutes of Health · US

Funding

IL-2:IL-15 : implications for cancer therapy (Investigator -Initiated Project)ZIASC004002 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI WALDMANN, THOMAS · 2009 to 2022
$22.9M
6 · The paper itself

Abstract

The high electric field across the plasma membrane might influence the conformation and behavior of transmembrane proteins that have uneven charge distributions in or near their transmembrane regions. Membrane depolarization of T cells occurs in the tumor microenvironment and in inflamed tissues because of K

Indexed as

Membrane PotentialsSignal TransductionCell Line, TumorHumansMembrane FluidityReceptors, Interleukin-15Receptors, Interleukin-2T-LymphocytesTumor MicroenvironmentReceptors, Interleukin-15Receptors, Interleukin-2

Identifiers

PMID29754714
PMCPMC6129476
OpenAlexW2799339858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.